A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.

The Trustees of Columbia University in the City of New York

Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of Ginkgo biloba

Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba

To supply the ginkgo biloba extract which contains no ginkgolic acid but the active ingredient of existing ginkgo biloba extract and which achieves significant effects in activation of the brain cells. The composition comprises nanoparticle ginkgo biloba extract as the active ingredient, which has the effect of brain function activation. The ginkgo biloba extract is free of ginkgolic acid and is made with the breakdown method, the combination of dry and wet process, crushing ginkgo biloba extract powder. The nanoparticle is 100 nm and below. The above composition has the form from the group consisting of condiments, food additives, food materials, food and drink, health food and drink, drugs, quasi drugs and feeding stuffs. The above health food and drink is for patients with abnormality in cerebral blood flow and metabolism and with the effect of brain function activation prevents or improves the symptom. The above drugs and quasi drugs are intended for human or animal use.

ginkgolic acid/イチョウ属

Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of Ginkgo biloba

Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba

Composition comprising nanoparticle Ginkgo biloba extract with the effect of brain function activation

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