BACKGROUND
The underlying pathology and natural course of Modic changes (MC) in the vertebral body marrow and high intensity zones (HIZs) in the annulus fibrosus is not completely clarified. These findings on magnetic resonance imaging (MRI) have initiated different treatments with little or unclear
METHODS
Laboratory based controlled in vivo study.
OBJECTIVE
To determine the in vivo effects of oral glucosamine sulfate on intervertebral disc degeneration.
BACKGROUND
Although glucosamine has demonstrated beneficial effect in articular cartilage, clinical benefit is uncertain. A Centers for