goyazensolide/lychnophora

BACKGROUND Lychnophora passerina (Mart ex DC) Gardn (Asteraceae), popularly known as Brazilian arnica, is used in Brazilian folk medicine to treat pain, rheumatism, bruises, inflammatory diseases and insect bites. OBJECTIVE Investigate the influence of the seasons on the anti-inflammatory and

Lychnophora ericoides Mart. (Asteraceae, Vernonieae) is a plant, endemic to Brazil, with occurrence restricted to the "cerrado" biome. Traditional medicine employs alcoholic and aqueous-alcoholic preparations of leaves from this species for the treatment of wounds, inflammation, and pain.

This work reports for the first time the production a furanoheliangolide (goyazensolide) by plant cell culture. Monitoring of the goyazensolide metabolism revealed that the maximum production occurred during the lag phase of the Lychnophora ericoides callus culture. The antiproliferative activity of

Excessive production of reactive oxygen species (ROS) by polymorphonuclear leucocytes (PMNLs) is thought to contribute to the pathology of many inflammatory diseases. Sesquiterpene lactones (STLs) seem to be important contributors to the anti-inflammatory activity of many species of Lychnophora

Crude extracts of Lychnophora pohlii were tested in vitro against trypomastigote forms of Trypanosoma cruzi, and the dichloromethane and methanol crude extracts from leaves plus inflorescences were found to have trypanocidal activity. The bioassay-guided fractionation of the extracts yielded seven

Crude extracts from the aerial parts of Lychnophora granmongolense (Asteraceae) were bioassayed for trypanocidal (trypomastigote forms of Trypanosoma cruzi) and analgesic (writhing test) activities. The crude ethyl acetate extract from the leaves plus inflorescences exhibited trypanocidal activity