Children who screened with sero test and microscopy. A 7-day high dose PQ will be provided for those with Pv seropositive and/or microscopic Pv/Po positive regardless of their symptoms.

Children who screened with sero test and microscopy. A 7-day high dose PQ will be provided only for symptomatic children with microscopic Pv/Po positive.

Malaria, Vivax

Multi-antigen sero-diagnostic test for measurement of P. vivax antibodies in plasma from finger stick as a means to detect hypnozoite carriers for treatment

Serological screen and treat

Weoe primary health centre

Serological Screen and Treat Trial for Plasmodium Vivax

Serological Screen and Treat Trial for P. Vivax: a Proof-of-concept Trial in Eastern Indonesia

Difference of P. vivax incidence by PCR between children serologically screened and those receiving routine care.

Difference in the time-to recur of P. vivax by PCR in SSAT and control arms.

Difference in the number of recurrent P. vivax by PCR in SSAT vs. control arms

Difference in the incidence of recurrent symptomatic P. vivax by microscopy in SSAT vs control arms

Seroconversion rate before and after intervention in SSAT and control arms.

Sensitivity and specificity of point-of-care antibody detection test vs. gold standard Luminex assay

Adverse event (AE) and Severe Adverse Event (SAE) of high dose PQ in schoolchildren.

Hb level in Sahli's method, Standard G6PD (SD Biosensor Inc., ROK) in comparison with (HemoCue AB, Angelholm, Sweden).

Sensitivity and specificity of microscopic examination to detect parasitemia from the shallow skin vasculature of the ankle (light microscopy-skin/LMS) compared to standard microscopic (light microscopy-finger/LMF) and PCR.

Mean duration time of gametocyte in LMS and LMF

Sensitivity and specificity of magneto-optical hemozoin detection (MOD) compared to standard malaria detection and PCR.

Hb level in Gazelle (Hemex Health, USA) in comparison with (HemoCue AB, Angelholm, Sweden).

Inge Sutanto

Professor

Indonesia University

Eijkman Institute for Molecular Biology

Eijkman Oxford Clinical Research Unit

Walter and Eliza Hall Institute of Medical Research

Rumah Sakit Umum Daerah Mimika

This study evaluates an experimental serological diagnostic technique intended to identify people at high risk of having dormant malaria parasites in their liver.
800 children living in eastern Indonesia will be individually randomised to the experimental serologic test or routine care.
Children in the serological diagnosis arm will be screened for the presence of antibodies to a previously validated panel of malaria antigens optimized for sensitivity to infection during the prior 9 months. Furthermore, they also will be screened by microscopy. If positive by either test, they will be treated for that malaria infection.
Children assigned to routine care will be screened by microscopic examination and treated when they show or have history of symptoms in the last 3 days.
After initial screening and treating according to diagnostic technique, all children will be actively followed for 9 months with PCR detection every 4 weeks.

Neonatal Hyperbilirubinemia

Shoklo Malaria Research Unit

Study on Newborn Babies With a Yellow Skin Color (Neonatal Jaundice Study)

A Prospective Cohort Study on the Etiology of Neonatal Hyperbilirubinemia in a Migrant and Refugee Population on the Thai-Myanmar Border

Establish the causes contributing to the development of neonatal hyperbilirubinemia in this population, including a detailed description of the clinical course of neonates with neonatal hyperbilirubinemia.

University of Oxford

Streptococcus Pneumoniae

A baseline blood culture will be obtained in all participants

Blood culture

Cultures from other sterile sites will be obtained per routine clinical practice

Other cultures per Clinical routine practice

Clinica Santa Catalina

Hospital CIMA San Jose

Instituto de Atencion Pediatrica

Hospital Clinica Biblica

Hospital Metropolitano

Costa Rica Epidemiological Study on S. Pneumoniae

Continuation of the Costa Rican Epidemiologic Surveillance for Invasive Pneumococcal Disease After Introduction of the Seven Valent Vaccine Into the Universal Vaccination Program

hemoglobinopathies/fever

Serological Screen and Treat Trial for Plasmodium Vivax

Study on Newborn Babies With a Yellow Skin Color (Neonatal Jaundice Study)

Costa Rica Epidemiological Study on S. Pneumoniae

Blood Transfusions in Thalassemia Patients, Complications and Adverse Effects

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