Study subjects will be administered a single dose of midazolam syrup (2.5 mg), metformin solution (50 mg), furosemide solution (1 mg), and one rosuvastatin tablet (10 mg) by mouth. Plasma will be collected from 0-96 hours. Urine will be collected from 0-24 hours.

Study subjects will be administered goldenseal 2 capsules (500 mg each) three times daily for 5 days. On day 6, subjects will be administered goldenseal 2 capsules (500 mg each), a single dose of midazolam syrup (2.5 mg), metformin solution (50 mg), furosemide solution (1 mg), and one tablet (10 mg) rosuvastatin. Goldenseal 2 capsules (500 mg each) will be administered approximately 4 and 8 hours later. Plasma will be collected from 0-96 hours. Urine will be collected from 0-24 hours.

Interaction Drug Food

goldenseal

Metformin

Furosemide

Midazolam oral solution

Rosuvastatin Oral Tablet

Washington State University

Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach

ratio of the area under of the plasma concentration time curve (AUC) of midazolam in the presence to absence of goldenseal

ratio of the maximum plasma concentration (Cmax) of midazolam in the presence to absence of goldenseal

hydrastinine/悪性腫瘍

Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach

科学に裏打ちされた最も完全な薬草データベース