Intervention chewing gum administration Each subject will be instructed to chew 1 or 2 pellets for 5 min 3 times a day (2 in the morning, 2 after the midday meal and 1 in the afternoon). Thus, the total daily intake of magnolol and honokiol in MX group will be 11.9 mg/day. The daily use of the two different chewing gums will be carried out for 12 months.

Intervention chewing gum Each subject will be instructed to chew 1 or 2 pellets for 5 min 3 times a day (2 in the morning, 2 after the midday meal and 1 in the afternoon). Thus, the total daily intake of magnolol and honokiol in MX group will be 11.9 mg/day. The daily use of the two different chewing gums will be carried out for 12 months.

Dental Caries

Chewing gum administration

Department of Surgery, Microsurgery and Medicine Sciences University of Sassari

WHO CC University of Milan

Effect of a Sugar-Free Chewing Gum Containing Magnolia Bark Extract on Caries Lesions in Healthy Adult Volunteers

Effect of a Sugar-free Chewing Gum Containing Magnolia Bark Extract on the Development of Caries Lesions in Healthy Adult Volunteers: a Randomized Controlled Intervention Trial

cumulative D2 or Filled Surface (D2 FS) increment (root and coronal surfaces combined).

Mutans streptococci and lactobacilli counts in saliva were assessed

and categorized using the dip-slide technique Interproximal-plaque pH of each subject was evaluated using pH indicator strips, Assessment of plaque pH value in the range of 4.0-7.0.

magnolia acuminata/inflammation

Effect of a Sugar-Free Chewing Gum Containing Magnolia Bark Extract on Caries Lesions in Healthy Adult Volunteers

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