mahonia leschenaultii/セロトニン

1. The extract from roots of Mahonia aquifolium as well as berbamine and oxyacanthine relaxed K(+)-precontracted rat aortal rings with IC50 values of about 20 mumol/l. 2. Relaxation was not inhibited by denudation of the endothelium or by premedication of the aortas with indomethacin, methylene blue

In the present study we tested the effect of four aporphine alkaloids, corytuberine, magnoflorine, isothebaine and isocorydine, on the isolated rat aorta. Corytuberine and magnoflorine showed little effect as relaxants in KCl- and noradrenaline-induced contractions. They did not inhibit the