osajin/アメリカハリグワ

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Osage orange pigments; complete structures of osajin and pomiferin.

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Isolation of 19alpha-H-lupeol from Maclura pomifera.

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A reinvestigation of the constituents of the Osage orange (maclura pomifera) yielded, in addition to the previously reported triterpenses (lupeol, butyrospermol, and lupan-3beta,20-diol), the pigments osajin and pomiferin, and a previously unreported constituent. The structure of this new compound

Photoactivated Semi-Synthetic Derivative of Osajin Selectively Interacts With G-quadruplex DNA

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Natural and synthetic small molecules targeting G-quadruplex are currently being studied. These peculiar DNA arrangements arise in guanine-rich sequences located in telomeres, oncogene promoters and in several viruses. Two semi-synthetic derivatives of osajin, a natural isoflavone from Maclura

Natural product inhibitors of carbonic anhydrase I and II isoenzymes: osajin and pomiferin.
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The aim of this study is to purify carbonic anhydrase I and II isoenzymes from human erythrocyte, isolate two natural products osajin (OSJ) and pomiferin (PMF) from Maclura pomifera fruits, and evaluate the in vitro effect of these natural metabolites on these isoenzymes. These natural products may

Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion.
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The present 15 days study was undertaken to evaluate the cardioprotective potential of the prenylated isoflavones osajin and pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite

Isoflavones from Maclura pomifera: structural elucidation and in silico evaluation of their interaction with PDE5.
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While osajin and pomiferin are known for their anticancer, antibacterial and antidiabetic properties, scandenone and auriculasin have been proposed as anti-inflammatory and antinociceptive agents. Curiously, these two couples of molecules are, from a chemical point of view, structural isomers which

Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors.
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Natural (iso)flavonoids have been recently reported to inhibit cyclic nucleotide phosphodiesterases (PDEs) and induce vasorelaxation, albeit the results described in the literature are discordant. The cGMP-selective isoform PDE-5A, in particular, represents the target of sildenafil and its analogues

Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid.
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Recent findings that many human chronic diseases are associated with oxidative stresses have instigated the search for dietary antioxidants. Many phytochemicals, particularly phenolic compounds, have been found to possess strong antioxidant activity and reduce the risks of those diseases.

Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.
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The major constituents from the fruits of Maclura pomifera are the prenylated isoflavones, osajin (1) and pomiferin (2). Their structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 2 showed potential inhibitory activity in histone deacetylase (HDAC)

Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera.
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Phytochemical analysis of the ethanolic extract of Maclura pomifera fruits yielded four new compounds (I-IV) along with eleven known compounds (V-XV). The crude extract exhibited significant activity towards cannabinoid receptors (CB1: 103.4% displacement; CB2: 68.8% displacement) and possibly

Antioxidative and EROD activities of osajin and pomiferin.
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The major constituents of fruits of Maclura pomifera are the prenylated isoflavones, osajin (1) and pomiferin (2). Since significant biological activities of extracts from the wood of M. pomifera were previously reported, the peroxynitrite scavenging activity, inhibition of lipid peroxidation,

Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider.
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We have investigated anticholinesterase potential of the methanol extracts from the leaf, wood, flower, twig, and stem bark of the female and male individuals and rhizodermis and fruit from the female tree of Maclura pomifera (Rafin.) Schneider (Moraceae) along with its major isoflavonoids; osajin

Osajin Inhibits Solar UV-Induced Cyclooxygenase-2 Expression Through Direct Inhibition of RSK2.
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Solar ultraviolet light (sUV) has been shown to promote the development of skin disorders including inflammation, photoaging, and skin carcinogenesis. Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera, commonly referred to as the Osage orange. In this study, we

HPLC determination of isoflavone levels in osage orange from the Midwest and southern United States.
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The fruit of the Maclura pomifera tree is a sustainable source for the pharmacologically interesting isoflavones, osajin and pomiferin. A reversed-phase HPLC method was developed to identify osage orange samples with high isoflavone content and to determine the optimum conditions for sample

Evidence on selective binding to G-quadruplex DNA of isoflavones from Maclura pomifera by mass spectrometry and molecular docking.
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G-quadruplex DNA stabilization mediated by small molecules is an attractive approach to modulate the transcription of guanine-rich sequences and contrast unregulated cell proliferation. Natural alkaloids have been reported to target this macromolecular arrangement, and such mechanism may be among

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osajin/アメリカハリグワ

Osage orange pigments; complete structures of osajin and pomiferin.

Isolation of 19alpha-H-lupeol from Maclura pomifera.

Photoactivated Semi-Synthetic Derivative of Osajin Selectively Interacts With G-quadruplex DNA

Natural product inhibitors of carbonic anhydrase I and II isoenzymes: osajin and pomiferin.

Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion.

Isoflavones from Maclura pomifera: structural elucidation and in silico evaluation of their interaction with PDE5.

Semi-synthetic derivatives of natural isoflavones from Maclura pomifera as a novel class of PDE-5A inhibitors.

Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid.

Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.

Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera.

Antioxidative and EROD activities of osajin and pomiferin.

Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider.

Osajin Inhibits Solar UV-Induced Cyclooxygenase-2 Expression Through Direct Inhibition of RSK2.

HPLC determination of isoflavone levels in osage orange from the Midwest and southern United States.

Evidence on selective binding to G-quadruplex DNA of isoflavones from Maclura pomifera by mass spectrometry and molecular docking.

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