phenethyl isothiocyanate/悪性腫瘍

Previously, Nutri-jelly, a novel edible nutritious gel for patients with chewing and swallowing difficulties, was shown to be effective in improving the quality of life of head and neck cancer patients. Recently, Nutri-PEITC jelly is recently developed by addition of Phenethyl Isothiocyanate

The Study Drug: PEITC is designed to cause build-up of specific molecules in cells, which may damage cancer cells and cause the cells to die. Study Drug Dose Levels: If you are found to be eligible to take part in this study, you will be assigned to a dose level of PEITC based on when you joined

OBJECTIVES: Primary - To determine whether oral phenethyl isothiocyanate (PEITC) affects urinary levels of biomarkers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in current smokers. Secondary - To determine the effect of GSTM1 genotype on PEITC's impact on urinary biomarkers

OBJECTIVES: I. Determine the maximum tolerated dose of oral phenethyl isothiocyanate in smokers. II. Measure the steady state pharmacokinetics of phenethyl isothiocyanate required to maintain a steady state of this substance during the hours of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)