phosphatide/inflammation

Specific alterations in glycerokinase and glycolytic pathways of glycerophosphate biosynthesis were detected in kidney under conditions of chronic bronchopulmonary inflammation. Considerable inhibition of glycerol kinase and glycerophosphate dehydrogenase resulted in pronounced decrease in content

Activated macrophages harvested from rat peritoneum were shown to contain phospholipase A1, A2 and lysophospholipase activities which were defined on a series of radiolabelled phospholipid substrates. During in vitro culture of these elicited macrophage populations, phospholipase enzymes were

In most demyelinating diseases, macrophages are believed to be active agents of myelin destruction. In experimental encephalomyelitis, these cells appear to strip off and ingest the myelin lamellae, and myelin debris has been observed within the cell body. We show here in vitro conditions in which

BACKGROUND Thrombosis and immune dysfunction are two important complications that result from the administration of parenteral nutrition. Endothelial cells within the vasculature are crucial components necessary for maintenance of normal coagulation and immune function. METHODS We compared the

levofloxacin, an amphipathic antibiotic. The aim of the present study was to design passive targeting liposomes, which might improve the antibacterial activity by accumulating in lung and reduce side effects such as neurotoxicity and hematotoxicity associated with direct injection of the drug.

A review is presented of the most important morphological and functional characteristics of the mast cell. The cell is ovoid and contains heparin-containing granules in the cytoplasm. These stain metachromatically. In addition to heparin, the granules contain histamine and other inflammatory

Platelet-activating factor (PAF) is a phospholipid that activates platelets, induces inflammation, and causes profound alteration in the cardiopulmonary system. PAF from rabbit basophils and hog leukocytes is 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC). Human and other mammalian serums

The pulmonary pathogens, Nocardia asteroides and Mycobacterium fortuitum classically produce a markedly different tissue response ranging from the acute suppurative lesion of nocardiosis to the granulomatous disease produced by the Mycobacterium. Both organisms have similar cell-wall associated

The results of the comparative study on the contents and activity of the enzymes of the system of oxidases of mixed function in the lungs and liver in rabbits, the specific features of phospholipid spectrum in the supernatant and microsomal fractions of the lungs and liver tissues are presented. The

Report of a 10-year-old boy with congenital hypoplasia of the intrahepatic bile ducts, the socalled MacMahon-Thannhauser-Syndrome. The patient had been suffering from a varying degree of jaundice since his 2nd day of life and from pruritus since his 21st month of life. Furthermore, he had

The localization and partial purification of a Ca2+-dependent, membrane associated phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) from BCG-induced rabbit alveolar macrophages is described. Phospholipase A activity was determined using autoclaved Escherichia coli, the phospholipids of

This study investigated the use of silymarin, an extract obtained from the milk thistle (Silybum marianum) and its effects as a possible hepatoprotector in Nile tilapia (Oreochromis niloticus). Silymarin was used as feed additive to the diet at a concentration of 0.1% (1 kg per ton of dry ration)

When rabbit peritoneal neutrophils were treated with glucocorticoids, their chemotactic response to stimulation by the chemoattractant fMet-Leu-Phe was markedly reduced. Preincubation of cells with glucocorticoids also decreased phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) activity in

Phyllanthus emblica L. (syn. Emblica officinalis) is commonly known as Indian gooseberry. In Ayurveda, P. emblica has been extensively used, both as edible (tonic) plants and for its therapeutic potentials. P. emblica is highly nutritious and is reported as an important dietary source of vitamin C,

Inhibition of prostaglandin synthesis by indomethacin, a drug with anti-inflammatory properties, has been attributed to its action on fatty acid cyclooxygenase. However, prostaglandin synthesis would also be inhibited if precursor fatty acids were not supplied. We find that indomethacin inhibits