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premature ejaculation/vomiting

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14 結果

Pharmaceutical composition for the treatment of premature ejaculation

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FIELD OF THE INVENTION The present invention relates to a pharmaceutical composition for the treatment of premature ejaculation, comprising clomipramine or pharmaceutically acceptable salts, sertraline or pharmaceutically acceptable salts and fluoxetine or pharmaceutically acceptable salts as active

Triazolobenzodiazepines and their use as vasopressin antagonists

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This application is a national stage entry under 35 U.S.C. .sctn. 371 of PCT/IB05/002711, filed Aug. 12, 2005 which claims benefit of Provisional Application No. 60/616,601, filed Oct. 5, 2004. This invention relates to novel compounds useful in therapy and to processes for the preparation thereof.

Triazole derivatives which inhibit vasopressin antagonistic activity

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This invention relates to novel compounds useful in therapy and to processes for the preparation of such compounds. It also relates to compositions containing such compounds, their use and intermediates used in their preparation. WO 01/87855 discloses triazole derivatives as inhibitors of glycine

Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof

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BACKGROUND OF THE INVENTION Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like

Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof

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BACKGROUND OF THE INVENTION Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like

Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof

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BACKGROUND OF THE INVENTION Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like

4,4-Disubstituted piperidines, and methods of use thereof

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BACKGROUND OF THE INVENTION Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in

4,4-Disubstituted piperidines, and methods of use thereof

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BACKGROUND OF THE INVENTION Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in

Piperidine-piperazine ligands for neurotransmitter receptors

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BACKGROUND OF THE INVENTION Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in

Piperidine-piperazine ligands for neurotransmitter receptors

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BACKGROUND OF THE INVENTION Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in

Piperidine-piperazine ligands for neurotransmitter receptors

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BACKGROUND OF THE INVENTION Dopamine, norepinephrine and serotonin are mammalian monoamine neurotransmitters that play important roles in a wide variety of physiological processes. Therefore, compounds that selectively modulate the activity of these three neurotransmitters, either individually, in

1,4-disubstituted piperazine ligands for neurotransmitter receptors

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BACKGROUND OF THE INVENTION Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed in animals and plants, occurring in vertebrates, fruits, nuts, and venoms. A number of congeners of serotonin are also found in nature and have been shown to possess a variety of peripheral and central nervous

P.sub.2x receptor DNA and protein sequence

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This invention relates to the P.sub.2 X-purinoceptor, its preparation and uses. The P.sub.2 X-purinoceptor is a ligand-gated ion channel; that is, the receptor itself forms an ion channel which opens when extracellular adenosine 5'-triphosphate (ATP) binds to the receptor. There are five other

Method of screening for compounds that bind P2x receptor

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This invention relate to the P.sub.2X -purinoceptor, its preparation and uses. The P.sub.2X -purinoceptor is a ligand-gated ion channel; that is, the receptor itself forms an ion channel which opens when extracellular adenosine 5'-triphosphate (ATP) binds to the receptor. There are five other
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