simalikalactone/simaba orinocensis

A new antimalarial quassinoid, namely, orinocinolide (1), was isolated from the root bark of Simaba orinocensis, together with the previously reported simalikalactone D (2). The structure of 1 was determined primarily from 1D and 2D NMR analysis, as well as by chemical derivatization. Compound 1 was

An antileukemic quassinoid simalikalactone D ( 17) and two anticancer phenolic compounds, emodin and tricin, were isolated from the wood of SIMABA MULTIFLORA (Simaroubaceae) as well as 8-hydroxycanthin-6-one ( 18) and coumarin. The constituents of the genus SIMABA are reviewed.

Two antimalarial quassinoids, gutolactone [1] and simalikalactone D [2], have been characterized by bioactivity-directed fractionation from the bark of Simaba guianensis collected near Manaus, Brazil. Compound 2 was previously isolated from Simaba multiflora and Quassia africana and shown to be an