To determine long-term outcome of infants with isolated or multiple soft markers but no structural or chromosomal abnormalities.A retrospective study of 78 pregnant women who were referred for amniocentesis and found to have soft markers including echogenic
Two half brothers (maternally related) had a similar syndrome of microhydrocephaly in both brothers and dilatation of the spinal canal with fusion of thalami in one brother. Primordial growth delay was noted in both brothers, with severe mental retardation in the surviving brother. Both had