In a chemotaxonomic study of the genus Thapsia (Apiaceae), root material of five taxa has been analysed for skin irritating sesquiterpene lactones and the coumarins, 6-methoxy-7-geranyloxycoumarin and scopoletin. Eight tetraesters of 2, 3, 7, 8, 10, 11-hexahydroxy-C (6)-guaianolide and two triesters