Optic fiber of 300um will be inserted at a distance of 8-10mm from the urethra. Each ablation lasts 6 minutes. Each fiber ablates at an energy of 1800J with a power of 2-3W. Treatment lasts for about 30 minutes.

Benign Prostatic Hyperplasia

Lower Urinary Tract Symptoms

The intervention will take place in an ambulatory setting of the interventional radiology department using the combined Echolaser XVG system. The treatment consists of a local anesthesia to the perineal region. Within each needle, an optic fiber of 300um will be inserted. Each ablation lasts 6 minutes and each fiber ablates1800J at a power of 2-3W. At the end of the ablation there is a pull-back of about 1cm from the original ablation location. According to the dimension of the middle lobe of the prostate, multiple pullbacks can be used. The total ablation is 3600J for 2 fibers (1800J/ fiber) at the power of 2-3W for a total duration of about 30minutes. At the end of the treatment, a 20mg bolus of i.v. corticosteroid is given for anti-edema and anti-inflammatory effects. Antibiotic therapy (Ciprofloxacin 500mg and gastroprotective therapy is given for 5 days. After an adequate amount of time for observation, the patient is dismissed.

Transperineal Focal Laser Ablation (TPLA)

Policlinico Tor Vergata (PTV) Foundation: UOC Department of Diagnostic Imaging and Interventional Radiology

Focal Laser Ablation for Benign Prostatic Hyperplasia

Efficacy of Ultrasound Guided Percutaneous Transperineal Laser Ablation in Benign Prostatic Hypertrophy Patients: Non-Pharmacological Interventional Study

Improvement of obstructive symptomatology correlated to BPH. The evaluation will be based on urodynamic studies of Qmax, post void and residual volume.

Evaluation of complications post TPLA treatment by MRI.

Evaluation of multi-parametric MRI of the prostate to quantify and/or preview coagulative necrosis after treatment and evaluate the response to transperineal laser ablation treatment for lower urinary tract symptoms.

Calculation and stratification of prodecural costs in in comparison to transurethral resection of the prostate (TURP).

Evaluation of quality of life quantified by the questionnaire (IPSS)

Evaluation of Quality of Life by International Index of Erectile Function (IIEF)

Create an international registry to assess long-term effectiveness of transperineal laser ablation for lower urinary tract symptoms, to assess functional outcomes, to assess safety, to determine baseline patient characteristics, to collect information on possible differences between centres applying treatment of transperineal laser ablation and to explore the optimal treatment indications and possible limitations. It an international prospective observational registry in which data is recorded of patients who are treated with transperineal laser ablation for lower urinary tract symptoms.

Guglielmo Manenti

Principal Investigator

University of Rome Tor Vergata

Patients with traumatic urethral injury associated with pelvic fractures who underwent urethroplasty

Trauma;Pelvis

No, Gender eligibility is based on biological gender identity

Urethroplasty

Urological Outcome of Posterior Urethroplasty in Patients in Assuit University

Urological Outcome of Posterior Urethroplasty in Patients With Pelvic Fracture and Urethral Distraction Defect in Assuit University

Abdelrahman Mohamed Abdelkader

Assiut University

Local anesthetic will be administered into the caudal space

Local anesthetic will be administered around the dorsal penile nerve

Hypospadias

After induction of general anesthesia, a caudal block will be performed using 0.75-1 mL/kg of 0.2% ropivacaine without epinephrine

Caudal block anesthesia

After induction of general anesthesia, a dorsal penile nerve block will be performed using 0.75-1 mL/kg of 0.2% ropivacaine without epinephrine

Dorsal penile nerve block anesthesia

Texas Children's Hospital

Effect of Caudal and Penile Block on Hypospadias Repair Complications

Post-operative follow-up to evaluate for post-operative complications including urethrocutaneous fistula, glans dehiscence, meatal stenosis, and urethral stricture

Post-operative pain will be assessed using the FLACC scale (faces, legs, activity, cry and consolability scale)

urethral stricture/edema

Focal Laser Ablation for Benign Prostatic Hyperplasia

Urological Outcome of Posterior Urethroplasty in Patients in Assuit University

Effect of Caudal and Penile Block on Hypospadias Repair Complications

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