Radioactive sources are manufactured for treating a tumor or cancerous area occurring around a conduit or duct in the body by emitting X-rays to destroy or reduce the tumors. The sources contain ytterbium which is substantially enriched in .sup.168Ytterbium and which is activated by exposure to neutron flux so as to contain a minor, but significant, fraction of X-ray and gamma-emitting .sup.169Ytterbium. The radioactive .sup.169Ytterbium source is inserted through a catheter or applicator or needle to the site of the cancer where it is maintained in position for a period of time to reduce the occurrence of cancer. The ytterbium also acts as an X-ray-opaque marker to facilitate external visualization of the sources during their delivery to the treatment site. The sources are encased in a shell to prevent direct contact of the radioactive material with human tissue. This encapsulation may be formed by welding a pair of end caps to a tubular member.

Best Medical International, Inc.

X-ray and gamma ray emitting temporary high dose rate brachytherapy source

The object of the invention is a method for preparing a compound of formula I ##STR1## wherein Me.sup.m+ is a lanthanide and n is a number from 1-3, is used for diagnosis of neoplasms. The compound is prepared by adding an aqueous solution of hydrazide hydrochloride to potassium hexachloroplatinate, the suspension is mixed about two hours at 50.degree. to 60.degree. C. then about 30 minutes at 80.degree. to 90.degree. C., and upon cooling the reaction mixture, the unreacted potassium hexachloroplatinate is separated, the solution is decanted and filtered, and the pH of the filtrate is brought to 3 to 5. Methionine is then added in a molar ratio of methionine to tetrachloroplatinate of 2:1-4:1 and upon careful mixing for about 30 minutes a metal salt is added and preferably ytterbium chloride, and tagged with Yb.sup.-169. The components are then mixed and the pH of the solution is brought to 4-6.5 and filtered through a sterile filter.

ytterbium/悪性腫瘍

X-ray and gamma ray emitting temporary high dose rate brachytherapy source

Method of pharmaceutic production

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