Green Vegetables and Women's Health
키워드
요약
날짜
마지막 확인: | 09/30/2015 |
처음 제출: | 11/01/2012 |
제출 된 예상 등록: | 11/07/2012 |
처음 게시 됨: | 11/13/2012 |
제출 된 마지막 업데이트: | 10/04/2015 |
마지막 업데이트 게시: | 10/06/2015 |
실제 연구 시작 날짜: | 10/31/2012 |
예상 기본 완료 날짜: | 08/31/2015 |
예상 연구 완료 날짜: | 08/31/2015 |
상태 또는 질병
개입 / 치료
Other: Broccoli and Brussels Sprouts
Dietary Supplement: Cruciferous Complete
Other: Placebo
단계
팔 그룹
팔 | 개입 / 치료 |
---|---|
Experimental: Broccoli and Brussels Sprouts Subjects will consume broccoli or Brussels sprouts (40g daily) for 8 weeks. | Other: Broccoli and Brussels Sprouts |
Experimental: Cruciferous Complete Subjects will take Cruciferous CompleteTM supplements (2 capsules, 3 times daily) for 8 weeks. | Dietary Supplement: Cruciferous Complete |
Placebo Comparator: Placebo Subjects will take placebo capsules (2 capsules, 3 times daily) for 8 weeks. | Other: Placebo |
자격 기준
공부할 수있는 연령 | 40 Years 에 40 Years |
공부할 수있는 성별 | Female |
건강한 자원 봉사자를 받아들입니다 | 예 |
기준 | Inclusion Criteria: - Premenopausal women between the ages of 40-50; premenopause is defined as regular menstrual cycles every 23-35 days - Willing to be randomized and compliant to the 3 study groups (whole cruciferous vegetable intake, cruciferous supplement or placebo capsules) - Able to give informed consent. Exclusion Criteria: - Urinary 2:16 > or = 3. - Current kidney or liver disease, adrenalectomy, or oophorectomy. - Use of tobacco products within the preceding three months, illegal use of medications or use of illegal drugs or substances. - Current use of antibiotics, cimetidine or black cohosh. - Systemic administration of estrogen, or use of non-prescription hormones, tamoxifen, or diabetes medication within the last three months. - Women under a physician-directed diet or those with a strong dislike of Brassica vegetables. - Presence of cancer in the last 5 years, with the exception of fully resected basal or squamous cell tumors. - Participation in an investigational drug study in the last 30 days. |
결과
1 차 결과 측정
1. Urinary 2:16 ratio [8 weeks]
2 차 결과 측정
1. Urinary 4OHE1 and 4OHE2 [8 weeks]
기타 결과 측정
1. Body composition [8 weeks]
2. Stability of urinary 2:16 ratio. [8 weeks]
3. Sub-study: Serum carotenoids and dietary intake [One blood draw on one day]
4. Sub-study: Serum carotenoids and body composition [One blood draw on one day]
5. Dietary Intake [8 weeks]