Effect of Garlic on Inflammatory Mediators
키워드
요약
기술
To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.
날짜
| 마지막 확인: | 02/28/2007 |
| 처음 제출: | 01/09/2006 |
| 제출 된 예상 등록: | 01/09/2006 |
| 처음 게시 됨: | 01/11/2006 |
| 제출 된 마지막 업데이트: | 03/18/2007 |
| 마지막 업데이트 게시: | 03/19/2007 |
| 실제 연구 시작 날짜: | 03/31/2006 |
| 예상 연구 완료 날짜: | 02/28/2007 |
상태 또는 질병
개입 / 치료
Drug: Garlic Oil Macerate
단계
자격 기준
| 공부할 수있는 연령 | 18 Years 에 18 Years |
| 공부할 수있는 성별 | All |
| 건강한 자원 봉사자를 받아들입니다 | 예 |
| 기준 | Inclusion Criteria: - 18 years of age and older - Normal subjects with BMI <25, obese subjects with BMI >30 - Subjects who have consented to adhere to the diet, regular weekly visits, and blood draws. Exclusion Criteria: - Subjects on any antioxidant medication. - Patient on non-steroidal anti-inflammatory drug. - On any agent with antioxidant properties. - History of drug or alcohol abuse. - Any life threatening disease. - On any agent with significant antioxidant properties. - Taking garlic extracts in the diet regularly. |
결과
1 차 결과 측정
1. 1. To examine the pharmacokinetics of the garlic oil macerate. [undefined]
2 차 결과 측정
1. 2. To examine the effect of garlic oil macerate on inflammatory mechanisms at the cellular and molecular level. [undefined]
