Pilot Study on the Tolerability of Dietary Dried Plum
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상태완료
스폰서
University of California, San Francisco
임상 시험: NCT01035372
BioSeek: nct01035372
키워드
요약
Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.
날짜
마지막 확인: | 01/31/2020 |
처음 제출: | 12/15/2009 |
제출 된 예상 등록: | 12/15/2009 |
처음 게시 됨: | 12/17/2009 |
제출 된 마지막 업데이트: | 02/25/2020 |
마지막 업데이트 게시: | 03/01/2020 |
실제 연구 시작 날짜: | 11/30/2009 |
예상 기본 완료 날짜: | 08/31/2010 |
예상 연구 완료 날짜: | 08/31/2010 |
상태 또는 질병
Healthy
Elderly
개입 / 치료
Dietary Supplement: dried plum
단계
-
팔 그룹
팔 | 개입 / 치료 |
---|---|
Experimental: dried plum subjects will have 25% by weight (~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder | Dietary Supplement: dried plum subjects will have 25% of their diet substituted by dried plum powder |
자격 기준
공부할 수있는 연령 | 50 Years 에 50 Years |
공부할 수있는 성별 | All |
건강한 자원 봉사자를 받아들입니다 | 예 |
기준 | Inclusion Criteria: - Age between 50 yrs and 75 yrs - Nonsmokers - Normal renal and hepatic function Exclusion Criteria: - Subjects who must follow a specific diet - Subjects on any daily medications that affect bone health - Subjects too heavy for the DEXA machine (weight limit 300 lbs) - Subjects whose BMD by DEXA indicates osteoporosis - Subjects unwilling to follow the diet specified - Pregnant women - Subjects who are unable to understand the consent form. |
결과
1 차 결과 측정
1. urinary calcium excretion [one month]
2 차 결과 측정
1. ability to tolerate the diet [one month]