[Siebold's mydriatic eyedrops].

I discovered two prescriptions of mydriatic eye drops that seemed to be written by Von Siebold. One prescription (prescription 1) belongs to the Siebold Memorial Hall in Nagasaki City, and the other (prescription 2) to the Municipal Museum in Ohzu City in Ehime Prefecture. Prescription 2 does not bear Siebold's signature but can be considered to have been written by him based on handwriting analysis. The major drugs in these prescriptions are Ex Belladonna and Ex Hyoscyamus. However, both prescriptions seem to have been written not only for mydriasis but also for antiphlogistic, analgesic and anticonvulsant effects in patients with eye disease. Based on the notes of the JP III and JP V, the mydriatics used by Siebold in operations such as for cataract were Ex Belladonna and Ex Hyoscyamus at a concentration of about 1%. Prescription 1. For a male with eye disease. Ex Belladonna 0.65 g; Laudanum 20 drops; Barium chloride 1.3 g; Rose water or chamomile water 124.4 g. Administer 3 times/day. Von Siebold (signature). Prescription 2. For Soya's daughter in Narutaki. Ex Hyoscyamus 0.39 g; Rose water 62.2 g. Administer some drops twice/day.