wallerian degeneration/potassium

The distribution of sodium and potassium channel proteins and the myelin associated glycoprotein (MAG) was studied by immunofluorescence during the early stages of Wallerian degeneration. Routine electron microscopy was also performed in order to investigate the success of the lesion in producing

Axons degenerate after injury and in neuropathies and disease via a self-destruction program whose mechanism is poorly understood. Axons that have lost connection to their cell bodies have altered electrical and synaptic activities, but whether such changes play a role in the axonal degeneration

1. Patch clamp studies of whole-cell ionic currents and biochemical studies of proliferation were carried out on Schwann cells of myelinated axons in explant segments of sciatic nerves of adult rabbit maintained in culture for 0-10 days. 2. Schwann cell proliferation, as assayed by [3H]thymidine

OBJECTIVE The aim of this study was to investigate changes in excitability properties associated with axonal regeneration in human neuropathy and a mouse Wallerian degeneration model. METHODS Threshold tracking was used to measure axonal excitability indices such as strength-duration time constant

Calcium-activated potassium ion channels SK and IK (small and intermediate conductance, respectively) may be important in the pathophysiology of pain following nerve injury, as SK channels are known to impose a period of reduced excitability after each action potential by afterhyperpolarization. We

BACKGROUND Amitriptyline is a tricyclic antidepressant drug used systemically for the management of neuropathic pain. Antidepressants, as a class of drugs with direct neurologic actions, are becoming widely used for the management of chronic pain, although their mechanisms are not entirely

Isolated nerve fibres of the median nerve of normal baboons and baboons kept on diets deficient in vitamin B12, and supplemented with potassium cyanide and potassium thiocyanate injections, were examined by the teased-fibre technique. Regression lines of internodal length on fibre diameter were

1. Whole-cell patch clamp studies were carried out on Schwann cells associated with myelinated and non-myelinated axons in the distal nerve stump of transected adult rabbit sciatic nerves which had undergone in vivo degeneration for 0-13 days. 2. Voltage-gated sodium current of Schwann cells

Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potassium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies