Effect of Arabinoxylan and Rye Kernels on Second Meal Responses

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StatusasBaigta

Rėmėjai

Aarhus University Hospital

Bendradarbiai

University of Aarhus

KLINIKINIS TYRIMAS: NCT01583270

BioSeek: NCT01583270

Raktažodžiai

Santrauka

Sedentary lifestyles and increasing obesity are main causes of the global increase in the prevalence of the metabolic syndrome (Mets) and type 2 diabetic (T2DM). Diet quality, particularly composition of carbohydrate play also a significant role. Barley, oat and rye may in addition to reducing the acute post prandial glucose response also reduce glucose response at a subsequent meal. Purified dietary fibre has been shown to reduce GI and affect levels of satiety hormones. In contrast, our knowledge of the physiological effect of arabinoxylan, which constitute a substantial part of dietary fibre in cereal products, is limited in relation to second meal effects. The investigators also lack knowledge of the second meal effect of arabinoxyan in combination with rye kernels.

Hypothesis: Porridge rich in arabinoxylan and/or whole rye kernels can increase the formation of short chain fatty acids and improve the glycemic response.

The aim of the present study is to compare the effect of porridge test meals based on purified arabinoxylan, rye kernels, a combination of arabinoxylan and rye kernels, and semolina porridge as control on acute postprandial response as well as response at a subsequent standardized meal. The study will be conducted in subjects with the metabolic syndrome. The primary endpoint is glucose response. Secondary endpoints are the following items: insulin, incretins, inflammatory markers, ghrelin, free fatty acids, metabolomics, breath hydrogen and subjective satiety feeling.

This project will improve opportunities for identifying and designing foods with low GI that is particularly suited to people who are at high risk of developing T2DM. The investigators also expect to gain a greater understanding of the metabolic fingerprint, as seen after ingestion of low-GI foods and thereby gain a molecular understanding of how low-GI foods affect health by altering metabolic processes. This will give us a deeper insight into the metabolic processes that are necessary for maintaining normal glucose homeostasis

apibūdinimas

Using a cross-over design, 15 subjects with Mets will consume test meals containing four different porridges in randomized order. Blood samples will be collected over 2 hours after ingestion of test meals and 2 hours after ingestion of a standard second lunch meal served 4 hours after the test meals. The amount of porridge and the standard lunch are equivalent to 50 g available carbohydrate. Visual Analog Scale (VAS) will be used for determination of subjective satiety feeling and measurements of breath hydrogen will be used as a marker for colon fermentation.

Datos

Paskutinį kartą patikrinta:	05/31/2013
Pirmasis pateikimas:	04/17/2012
Numatytas registravimas pateiktas:	04/22/2012
Pirmas paskelbtas:	04/23/2012
Paskutinis atnaujinimas pateiktas:	06/17/2013
Paskutinis atnaujinimas paskelbtas:	06/18/2013
Faktinė studijų pradžios data:	03/31/2012
Numatoma pirminio užbaigimo data:	09/30/2012
Numatoma studijų užbaigimo data:	09/30/2012

Būklė ar liga

Metabolic Syndrome

Intervencija / gydymas

Dietary Supplement: Arabinoxylan

Dietary Supplement: rye kernels

Dietary Supplement: arabinoxylan and rye kernels

Dietary Supplement: semolina

Fazė

Rankų grupės

Ranka	Intervencija / gydymas
Experimental: Arabinoxylan Porridge rich in arabinoxylan. 50 g available carbohydrate	Dietary Supplement: Arabinoxylan Porridge rich in arabinoxylan
Experimental: rye kernels Porridge made from rye kernels. 50 g available carbohydrate	Dietary Supplement: rye kernels Porridge made of rye kernels
Experimental: arabinoxylan and rye kernels Porridge made of rye kernels and arabinoxylan. 50g available carbohydrate	Dietary Supplement: arabinoxylan and rye kernels Porridgde made of rye kernels and arabinoxylan
Experimental: semolina Semoline porridge. 50 g available carbohydrate	Dietary Supplement: semolina Semoline porridge. control meal.

Tinkamumo kriterijai

Amžius, tinkami studijuoti	18 Years Į 18 Years
Tinkamos studijoms lytys	All
Priima sveikus savanorius	Taip
Kriterijai	Inclusion Criteria: Central obesity (Female > 94 cm; Male > 80 cm) with two of the following: 1. fasting triglyceride (> 1,7 mmol/L), 2. HDL-cholesterol: (Female:< 1,03 mmol/L; Male:< 1,29 mmol/L), 3. blood pressure (≥ 130/85 mmHg) and 4. fasting plasma glucose (≥ 5,6 mmol/L)). Subjects who are in medical treatment with lipid and blood pressure-lowering drugs can continue with their habitual treatment provided that the treatment is stable throughout the trial. Exclusion Criteria: - fasting plasma glucose > 7,0 mmol/l, - fasting plasma triglyceride > 5,0 mmol/l, - blood pressure > 160/100 mmHg , - legal incapacity , endocrine, cardiovascular or kidney disease, - BMI > 38kg/m2, - corticosteroid treatment, - alcohol or drug addiction and - pregnancy or lactation.

Rezultatas

Pirminės rezultatų priemonės

1. Glucose response after second meal [2 hours]

Antrinės rezultatų priemonės

1. Plasma response after second meal [2 hours]

Plasma insulin, incretins, ghrelin, short chain fatty acids, freee fatty acids, inflammation markers, and metabolomics.

2. Plasma response after test meal [2 hours]

Plasma glucose, insulin, incretins, short chain fatty acids, free fatty acids, metabolomisc.

3. Breath hydrogen after second meal [2 hours]

Breath hydrogen as marker for colon fermentation

4. Breath hydrogen after testmeal [2 hours]

Breath hydrogen as marker for colen fermentation

5. Satiety feeling after second meal [2 hours]

6. Satiety feeling after test meal [2 hours]

Effect of Arabinoxylan and Rye Kernels on Second Meal Responses

Raktažodžiai

arabinoxylan

uždegimas

nutukimas

carbohydrate

rugys

sėjamasis rugys