Sucralose, Stevia, Gut Microbiome and Glucose Metabolism
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Rėmėjai
University of Minnesota
KLINIKINIS TYRIMAS: NCT02800707
BioSeek: NCT02800707
Raktažodžiai
Santrauka
This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women.
apibūdinimas
This study will determine the influence of two non-caloric sweeteners on glucose metabolism via the gut microbiome in adult men and women aged 35-55 years.
Datos
| Paskutinį kartą patikrinta: | 02/28/2018 |
| Pirmasis pateikimas: | 06/09/2016 |
| Numatytas registravimas pateiktas: | 06/09/2016 |
| Pirmas paskelbtas: | 06/14/2016 |
| Paskutinis atnaujinimas pateiktas: | 03/20/2018 |
| Paskutinis atnaujinimas paskelbtas: | 03/21/2018 |
| Faktinė studijų pradžios data: | 01/02/2017 |
| Numatoma pirminio užbaigimo data: | 01/30/2018 |
| Numatoma studijų užbaigimo data: | 01/30/2018 |
Būklė ar liga
Impaired Glucose Tolerance
Intervencija / gydymas
Other: Sucralose
Other: Stevia
Fazė
-
Rankų grupės
| Ranka | Intervencija / gydymas |
|---|---|
| Active Comparator: Sucralose Participants will be asked to consume 180 mg/day of sucralose (in the form of capsules which is equivalent to three 12-oz cans of diet soda) for 14 days. According to the FDA, a 150 lb. person may consume up to 340 mg/day of sucralose (or 5.5 12-oz cans of sucralose-sweetened diet soda). | Other: Sucralose Sweetner |
| Active Comparator: Stevia Participants will be asked to consume 180 mg/day of stevia (in the form of capsules which is equivalent to three 12-oz cans of diet soda) for 14 days. According to the FDA, a 150 lb. person may consume up to 800 mg/day of stevia (or about 12 cans of stevia-sweetened diet soda). | Other: Stevia Sweetner |
Tinkamumo kriterijai
| Amžius, tinkami studijuoti | 35 Years Į 35 Years |
| Tinkamos studijoms lytys | All |
| Priima sveikus savanorius | Taip |
| Kriterijai | Inclusion Criteria: Generally health adult men and women aged 35-55 years old - Exclusion Criteria:Adults will not be eligible who have chronic disease (cancer, CHD, diabetes, chronic kidney disease); pregnant or breast feeding; menopausal; has a history of bariatric surgery; taking prednisone/steroids, taking medication for PCOS, or take medications that influence blood glucose. - |
Rezultatas
Pirminės rezultatų priemonės
1. 2-hour glucose [14 days]
An oral glucose tolerance test will be administered before and after consuming assigned sweetener to determine change in 2-hour glucose
Antrinės rezultatų priemonės
1. Gut microbiome [14 days]
Gut microbiota will be measured before and after consuming assigned sweetener to determine change in gut microbiota.
