Biomarkers of Broccoli Intake: A Pilot Study
Raktažodžiai
Santrauka
apibūdinimas
Consumption of Brassica vegetables is inversely associated with incidence of several cancers, including cancer of the lung, stomach, liver, colon, rectum, breast, endometrium, and ovaries. Brassicas are a good source of many nutrients, but the unique characteristic of Brassicas is their rich content of glucosinolates. Breakdown products of indole glucosinolates in Brassica vegetables show promise for reducing the risk of cancer, but have received comparatively less research attention than those of aliphatic glucosinolates. The aim of this study is to investigate plasma and urinary metabolites of indole glucosinolates from broccoli and to identify novel metabolites that may have roles in reducing cancer risk.
Datos
| Paskutinį kartą patikrinta: | 10/31/2017 |
| Pirmasis pateikimas: | 09/14/2017 |
| Numatytas registravimas pateiktas: | 09/17/2017 |
| Pirmas paskelbtas: | 09/18/2017 |
| Paskutinis atnaujinimas pateiktas: | 11/19/2017 |
| Paskutinis atnaujinimas paskelbtas: | 11/20/2017 |
| Faktinė studijų pradžios data: | 11/05/2017 |
| Numatoma pirminio užbaigimo data: | 11/16/2017 |
| Numatoma studijų užbaigimo data: | 11/16/2017 |
Būklė ar liga
Intervencija / gydymas
Other: Broccoli
Fazė
Rankų grupės
| Ranka | Intervencija / gydymas |
|---|---|
| Experimental: Broccoli Subjects will consume a dose of broccoli on day 11 | Other: Broccoli All subjects will eat broccoli on day 11 |
Tinkamumo kriterijai
| Amžius, tinkami studijuoti | 21 Years Į 21 Years |
| Tinkamos studijoms lytys | All |
| Priima sveikus savanorius | Taip |
| Kriterijai | Inclusion Criteria: - Non tobacco user - Cancer Free - Not currently taking glucosinolate/isothiocyanate containing supplements Exclusion Criteria: - Type 2 diabetes requiring the use of diabetes pills, insulin, or non-insulin shots - Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol, or Miradon (anisindione) - History of bariatric surgery or nutrient malabsorption disease (such as celiac disease) or other metabolic disorders requiring special diet recommendations - Pregnant, lactating, or intending to become pregnant during the study period - Crohn's disease or diverticulitis - Suspected or known strictures, fistulas or physiological/mechanical GI obstruction - Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion) |
Rezultatas
Pirminės rezultatų priemonės
1. The change in glucosinolate metabolites will be measured in blood plasma and urine. [On Day 11]
