Carbon-11 Labeled Sarcosine in Prostate Cancer
Raktažodžiai
Santrauka
apibūdinimas
Tissue levels of the amino acid sarcosine are elevated in prostate cancer compared to normal prostate tissues and further increased in metastases from prostate cancer. This research project is designed to test whether 11C-sarcosine (a chemical that is linked to short lived radioactivity) would be useful to detect prostate cancer in men using PET/CT imaging. The uptake and distribution of 11C-sarcosine in men with known or suspected prostate cancer will be determined and compared with results from 11C-choline PET/CT.
Datos
| Paskutinį kartą patikrinta: | 10/31/2017 |
| Pirmasis pateikimas: | 02/26/2015 |
| Numatytas registravimas pateiktas: | 05/31/2015 |
| Pirmas paskelbtas: | 06/03/2015 |
| Paskutinis atnaujinimas pateiktas: | 11/06/2017 |
| Paskutinis atnaujinimas paskelbtas: | 11/08/2017 |
| Faktinė studijų pradžios data: | 05/31/2015 |
| Numatoma pirminio užbaigimo data: | 02/07/2017 |
| Numatoma studijų užbaigimo data: | 02/07/2017 |
Būklė ar liga
Intervencija / gydymas
Drug: 11C-sarcosine
Drug: Prostate Cancer
Fazė
Rankų grupės
| Ranka | Intervencija / gydymas |
|---|---|
| Prostate Cancer Subjects will receive two PET/CT examinations, one with 11C-sarcosine and one with 11C-choline. These scans will take 30-45 minutes each. | Drug: Prostate Cancer Radiotracer injection for PET/CT scan |
| Healthy Volunteer Subjects will receive one PET/CT examination, with 11C-sarcosine. This scan will take approximately 90 minutes. |
Tinkamumo kriterijai
| Amžius, tinkami studijuoti | 40 Years Į 40 Years |
| Tinkamos studijoms lytys | Male |
| Mėginių ėmimo metodas | Non-Probability Sample |
| Priima sveikus savanorius | Taip |
| Kriterijai | Inclusion Criteria: - Males 40 years of age or older - Confirmed or suspected prostate cancer and will undergo a planned tissue biopsy of the known or suspected tumor (Prostate Cancer Group 1 only) Exclusion Criteria: - Active malignancy (except basal cell or squamous cell skin cancer) within the last 2 years - Body weight > 350 lbs (158 kg) - Prisoners - Subject not willing or able to sign informed consent |
Rezultatas
Pirminės rezultatų priemonės
1. Evaluation of biodistribution of 11C-sarcosine in prostate cancer patients [One Month]
2. Evaluation of radiation dosimetry of 11C-sarcosine in healthy volunteers [One Month]
Antrinės rezultatų priemonės
1. Comparison of the uptake measures of 11C-sarcosine with those from 11C-choline [One Month]
2. Evaluation of underlying metabolic pathways of sarcosine in prostate cancer tissues obtained from tissue materials [One Month]
3. Evaluation of the relationship between sarcosine (and metabolite) tissue concentrations and 11C-sarcosine/11C-choline plasma and tissue uptake measures [One Month]
