CRRT Timing in Sepsis-associated AKI in ICU
Raktažodžiai
Santrauka
apibūdinimas
In our study, 460 patients with SAKI at KDIGO 2 from multicenter in China will be recruited. And then the patients will be divided into early group and delayed group randomly. In the early group, CRRT was started immediately after randomization. In the delay group, CRRT was initiated if at least one of the following criteria was met: KDIGO 3, severe hyperkalemia, pulmonary edema, blood urea nitrogen level higher than 112 mg per deciliter after randomization. Overall survival at day 90 will be observed in order to understand whether different CRRT strategy would affect the outcomes of SAKI.
Datos
Paskutinį kartą patikrinta: | 05/31/2020 |
Pirmasis pateikimas: | 05/31/2017 |
Numatytas registravimas pateiktas: | 05/31/2017 |
Pirmas paskelbtas: | 06/04/2017 |
Paskutinis atnaujinimas pateiktas: | 06/15/2020 |
Paskutinis atnaujinimas paskelbtas: | 06/17/2020 |
Faktinė studijų pradžios data: | 08/21/2019 |
Numatoma pirminio užbaigimo data: | 02/27/2022 |
Numatoma studijų užbaigimo data: | 05/27/2022 |
Būklė ar liga
Intervencija / gydymas
Procedure: continuous renal replacement therapies
Fazė
Rankų grupės
Ranka | Intervencija / gydymas |
---|---|
Experimental: early group In the early group, continuous renal replacement therapies was started within 8 hours after randomization. | |
Experimental: delayed group In the delayed group, continuous renal replacement therapies was initiated if at least one of the following criteria was met: KDIGO 3, severe hyperkalemia, pulmonary edema, blood urea nitrogen level higher than 112 mg per deciliter after randomization. |
Tinkamumo kriterijai
Amžius, tinkami studijuoti | 18 Years Į 18 Years |
Tinkamos studijoms lytys | All |
Priima sveikus savanorius | Taip |
Kriterijai | Inclusion criteria 1. Age between 18 and 90 years. 2. Patients admitted into ICU with Sepsis (sepsis-3) compatible with the diagnosis of AKI at stage 2 of KDIGO classification. 3. Informed consent provided by the patient or person with decisional responsibility. Exclusion criteria 1. Presence of one of the emergent CRRT conditions before randomization: 1. Hyperkalemia > 6.0 mmol/L or > 5.5 mmol/L persisting despite medical treatment. 2. Acute pulmonary edema due to fluid overload responsible for severe hypoxemia requiring oxygen flow rate > 5 L/min to maintain a percutaneous oxygen saturation (SpO2) > 95% or a fraction of inspiration oxygen (FiO2) > 50% in patients already on invasive or non-invasive mechanical ventilation and despite diuretic therapy. 3. Blood urea nitrogen (BUN) > 112 mg/dl (40 mmol/L). 2. Pre-existing severe chronic renal failure [estimated glomerular filtration rate (eGFR) < 30 ml/min]. 3. Previous renal replacement therapy. 4. Prior kidney t |
Rezultatas
Pirminės rezultatų priemonės
1. overall mortality [90 days]
Antrinės rezultatų priemonės
1. recovery rate of renal function [90 days]
2. organ dysfunction [90 days]
3. length of ICU stay and in-hospital stay [90 days]
4. the percentage of receipt of CRRT at least once in the delayed group [90 days]
5. the number of days alive without CRRT, mechanical ventilation and vasopressor [90 days]
6. difference of the Sequential Organ Failure Assessment score [28 days]
7. the rate of complications potentially related to CRRT [90 days]