Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns
Raktažodžiai
Santrauka
apibūdinimas
The incidence of cerebrovascular accidents (CVA) occurring perinatally is relatively high and aspects of the multifactorial pathophysiology remain unclear. Elevated homocysteine concentrations are shown to be associated with an increased risk for CVA in newborns. We want to study the possible homocysteine lowering effect of folinic acid in newborns.
We will include newborns in our prospective randomized folinic acid intervention study from patients admitted to our Neonatal Intensive Care Unit. We will measure total homocysteine (tHcy) and folate concentrations at three time points. The intervention group will be treated with folinic acid (70 µg/kg/day) for two weeks.
Datos
| Paskutinį kartą patikrinta: | 03/31/2009 |
| Pirmasis pateikimas: | 04/05/2009 |
| Numatytas registravimas pateiktas: | 04/05/2009 |
| Pirmas paskelbtas: | 04/06/2009 |
| Paskutinis atnaujinimas pateiktas: | 05/04/2009 |
| Paskutinis atnaujinimas paskelbtas: | 05/05/2009 |
| Faktinė studijų pradžios data: | 12/31/2002 |
| Numatoma pirminio užbaigimo data: | 10/31/2003 |
| Numatoma studijų užbaigimo data: | 10/31/2003 |
Būklė ar liga
Intervencija / gydymas
Drug: folinic acid
Fazė
Rankų grupės
| Ranka | Intervencija / gydymas |
|---|---|
| Experimental: folinic acid Folinic acid was given for two weeks as 5-formyltetrahydrofolate (10 mg/ml) (Pharmachemie bv). This solution was administered either intravenously (first week) or orally. To lower homocysteine in adults 5 mg/day folic acid is frequently used. Using an average bodyweight of 70 kg for adults we calculated a daily dose of 70 microgram/kg/day for our newborns | Drug: folinic acid Folinic acid was given for two weeks as 5-formyltetrahydrofolate (10 mg/ml) (Pharmachemie bv). This solution was administered either intravenously (first week) or orally. To lower homocysteine in adults 5 mg/day folic acid is frequently used. Using an average bodyweight of 70 kg for adults we calculated a daily dose of 70 microgram/kg/day for our newborns. |
| No Intervention: 2 control subjects admitted at the Neonatal Intensive Care Unit (NICU) |
Tinkamumo kriterijai
| Tinkamos studijoms lytys | All |
| Priima sveikus savanorius | Taip |
| Kriterijai | Inclusion Criteria: - admitted at our NICU Exclusion Criteria: - midline defects - Extracorporeal membrane oxygenation (ECMO) treatment - blood transfusion - overt renal failure |
Rezultatas
Pirminės rezultatų priemonės
1. lowering total homocysteine concentrations [2 weeks]
