Effect of Garlic on Inflammatory Mediators
Raktažodžiai
Santrauka
apibūdinimas
To investigate the pharmacokinetics of one of the garlic oil macerate, Ajoene, the anti-inflammatory effect of garlic oil macerate on the pro-inflammatory transcription factor NF-kB, it's activating proteins, including IkB, IkB Kinases a and B (IKKa and IKKB) and the pro-inflammatory NF-kB-regulated proteins, c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), plasminogen activated protein-1 (PAI-1)and the effect of garlic oil macerate intake on platelet activation in normal subjects.
Datos
| Paskutinį kartą patikrinta: | 02/28/2007 |
| Pirmasis pateikimas: | 01/09/2006 |
| Numatytas registravimas pateiktas: | 01/09/2006 |
| Pirmas paskelbtas: | 01/11/2006 |
| Paskutinis atnaujinimas pateiktas: | 03/18/2007 |
| Paskutinis atnaujinimas paskelbtas: | 03/19/2007 |
| Faktinė studijų pradžios data: | 03/31/2006 |
| Numatoma studijų užbaigimo data: | 02/28/2007 |
Būklė ar liga
Intervencija / gydymas
Drug: Garlic Oil Macerate
Fazė
Tinkamumo kriterijai
| Amžius, tinkami studijuoti | 18 Years Į 18 Years |
| Tinkamos studijoms lytys | All |
| Priima sveikus savanorius | Taip |
| Kriterijai | Inclusion Criteria: - 18 years of age and older - Normal subjects with BMI <25, obese subjects with BMI >30 - Subjects who have consented to adhere to the diet, regular weekly visits, and blood draws. Exclusion Criteria: - Subjects on any antioxidant medication. - Patient on non-steroidal anti-inflammatory drug. - On any agent with antioxidant properties. - History of drug or alcohol abuse. - Any life threatening disease. - On any agent with significant antioxidant properties. - Taking garlic extracts in the diet regularly. |
Rezultatas
Pirminės rezultatų priemonės
1. 1. To examine the pharmacokinetics of the garlic oil macerate. [undefined]
Antrinės rezultatų priemonės
1. 2. To examine the effect of garlic oil macerate on inflammatory mechanisms at the cellular and molecular level. [undefined]
