Effects of Blueberry on Gut Microbiota and Metabolic Syndrome
Raktažodžiai
Santrauka
Datos
| Paskutinį kartą patikrinta: | 04/30/2020 |
| Pirmasis pateikimas: | 07/05/2017 |
| Numatytas registravimas pateiktas: | 08/27/2017 |
| Pirmas paskelbtas: | 08/28/2017 |
| Paskutinis atnaujinimas pateiktas: | 05/03/2020 |
| Paskutinis atnaujinimas paskelbtas: | 05/04/2020 |
| Faktinė studijų pradžios data: | 08/31/2017 |
| Numatoma pirminio užbaigimo data: | 01/13/2019 |
| Numatoma studijų užbaigimo data: | 11/30/2021 |
Būklė ar liga
Intervencija / gydymas
Dietary Supplement: Blueberry powder
Dietary Supplement: Blueberry placebo powder
Fazė
Rankų grupės
| Ranka | Intervencija / gydymas |
|---|---|
| Experimental: Blueberry powder | Dietary Supplement: Blueberry powder Subjects will consume blueberry powder during 8 weeks to test the possible effects of blueberries on gut microbiota composition and on metabolic syndrome parameters. |
| Placebo Comparator: Blueberry placebo powder | Dietary Supplement: Blueberry placebo powder Subjects will consume blueberry placebo powder to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and the active treatment (blueberry powder). |
Tinkamumo kriterijai
| Amžius, tinkami studijuoti | 18 Years Į 18 Years |
| Tinkamos studijoms lytys | All |
| Priima sveikus savanorius | Taip |
| Kriterijai | Inclusion Criteria: - Men and premenopause women in good health - Caucasians - At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men - At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L Exclusion Criteria: - Metabolic disorders (hypertension, diabetes, hypercholesterolemia) - Regular use of medication affecting study parameters - Use of natural health product in the last 3 months - Use of antibiotics in the last 3 months - Nicotine users - Allergy or intolerance for blueberries - Blueberry taste aversion - More than 2 alcohol drinks par day - Particular dietary habits (vegetarism, gluten-free diet, cetogenic diet...) - Weight change of more than 5% in the last 3 months - Surgery in the last 3 months or planed during the study |
Rezultatas
Pirminės rezultatų priemonės
1. Changes in plasma insulin/glucose of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
2. Changes in plasma lipids/lipoproteins of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
Antrinės rezultatų priemonės
1. Changes in gene expression in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
2. Changes in metabolites concentration in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
3. Changes in the gut microbiota composition in overweight/obese men and women taking either blueberry powder or placebo blueberry powder [3-6 months]
4. Changes in blood pressure of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
5. Changes in intestinal integrity of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
6. Changes in inflammation biomarkers of overweight/obese men and women taking either blueberry powder or placebo blueberry powder [12 months]
