Effects of Sea Buckthorn Oil on Dry Eye
Raktažodžiai
Santrauka
apibūdinimas
The objective is to study whether regular consumption of sea buckthorn berry oil can relieve the symptoms of dry eye syndrome. The study design is a parallel randomized double-blind placebo controlled trial. The participants daily consume sea buckthorn or placebo oil for 3 months. The dry eye symptoms will be monitored during the study using a validated questionnaire. In addition clinical dry eye tests are made by an ophthalmologist three time during the study. Samples will be taken for tear film lipid and cytokine analyses. Blood samples for the analyses of inflammatory markers are also obtained. The cytokine and other inflammation marker analyses are optional. The symptoms will be monitored and clinical tests made also 4 weeks after the participants have stopped consuming the study oils.
Datos
| Paskutinį kartą patikrinta: | 02/28/2017 |
| Pirmasis pateikimas: | 08/20/2008 |
| Numatytas registravimas pateiktas: | 08/20/2008 |
| Pirmas paskelbtas: | 08/21/2008 |
| Paskutinis atnaujinimas pateiktas: | 03/18/2018 |
| Paskutinis atnaujinimas paskelbtas: | 03/19/2018 |
| Faktinė studijų pradžios data: | 08/31/2008 |
| Numatoma pirminio užbaigimo data: | 02/28/2009 |
| Numatoma studijų užbaigimo data: | 02/28/2009 |
Būklė ar liga
Intervencija / gydymas
Dietary Supplement: SB
Dietary Supplement: PL
Fazė
Rankų grupės
| Ranka | Intervencija / gydymas |
|---|---|
| Experimental: SB Sea buckthorn oil group | Dietary Supplement: SB Dosage 2 g/d, frequency twice/d, duration 3 months |
| Placebo Comparator: PL Placebo group | Dietary Supplement: PL Placebo comparison, dosage 2 g/d, frequency twice/d, duration 3 months |
Tinkamumo kriterijai
| Amžius, tinkami studijuoti | 20 Years Į 20 Years |
| Tinkamos studijoms lytys | All |
| Priima sveikus savanorius | Taip |
| Kriterijai | Inclusion Criteria: - Dry eye symptoms Exclusion Criteria: - Severe illness - Anticholinergic drugs - Smoking |
Rezultatas
Pirminės rezultatų priemonės
1. Symptom severity: symptom questionnaires and clinical dry eye tests [3 months intervention + 1 month after the intervention]
Antrinės rezultatų priemonės
1. Tear film lipid profile, tear cytokines, inflammation mediators in blood [3 months intervention + 1 month after the intervention]
