High-dose Antioxidants for Central Serous Chorioretinopathy
Raktažodžiai
Santrauka
Datos
Paskutinį kartą patikrinta: | 11/30/2009 |
Pirmasis pateikimas: | 08/19/2009 |
Numatytas registravimas pateiktas: | 08/19/2009 |
Pirmas paskelbtas: | 08/20/2009 |
Paskutinis atnaujinimas pateiktas: | 12/28/2009 |
Paskutinis atnaujinimas paskelbtas: | 12/29/2009 |
Faktinė studijų pradžios data: | 11/30/2004 |
Numatoma pirminio užbaigimo data: | 11/30/2008 |
Numatoma studijų užbaigimo data: | 05/31/2009 |
Būklė ar liga
Intervencija / gydymas
Drug: antioxidants tablets
Fazė
Rankų grupės
Ranka | Intervencija / gydymas |
---|---|
Experimental: antioxidant tablets the study arm received antioxidant tablets (Icaps) for 3 months or until the resolution of the disease | |
Placebo Comparator: placebo tablets the control arm received placebo tablets for 3 months or until the resolution of the disease |
Tinkamumo kriterijai
Amžius, tinkami studijuoti | 30 Years Į 30 Years |
Tinkamos studijoms lytys | All |
Priima sveikus savanorius | Taip |
Kriterijai | Inclusion Criteria: 1. patients with acute central serous chorioretinopathy within 6 weeks of onset 2. age between 30-50 years 3. new or recurrent attack (the symptom-free period should longer than 6 months) 4. fluorescein angiography (FA) confirmed the diagnosis with the inkblot or smoke-stack leakage and the optical coherence tomography (OCT) showed definite subretinal fluid 5. patients' ability for proper follow up. Exclusion Criteria: 1. chronic central serous chorioretinopathy(longer than 6 weeks) 2. complicated central serous chorioretinopathy such as secondary choroidal neovascularization (CNV) that detected from FA 3. pregnancy, steroid user and patients that contraindicated for high dose antioxidants therapy such as heavy smokers, lung cancer, thyrotoxicosis, renal stone and anemia (hematocrit less than 30%). |
Rezultatas
Pirminės rezultatų priemonės
1. visual acuity and central macular thickness [6 months]
Antrinės rezultatų priemonės
1. fluorescein leakage at the third month [6 months]