Stevia Extract and Glucose Homeostasis
Raktažodžiai
Santrauka
apibūdinimas
The study is a three-arm crossover trial involving participants attending the Lab on 3 different occasions (separated by 3-5 day washout period), where they will be administered water, sugar solution (65g), water and stevia extract (5g) solution. The solution will be followed by a consumption of a fixed meal (after 30 minutes). Breakfast will be standardised. Capillary blood glucose will be collected every 30 min until 2 hours post meal. Venous blood samples will be collected before the intake of the solution and at 2 hours after meal intake.
Datos
| Paskutinį kartą patikrinta: | 03/31/2020 |
| Pirmasis pateikimas: | 04/01/2020 |
| Numatytas registravimas pateiktas: | 04/01/2020 |
| Pirmas paskelbtas: | 04/05/2020 |
| Paskutinis atnaujinimas pateiktas: | 04/06/2020 |
| Paskutinis atnaujinimas paskelbtas: | 04/08/2020 |
| Faktinė studijų pradžios data: | 03/02/2020 |
| Numatoma pirminio užbaigimo data: | 02/14/2021 |
| Numatoma studijų užbaigimo data: | 02/14/2021 |
Būklė ar liga
Intervencija / gydymas
Other: sugar replacements
Fazė
Rankų grupės
| Ranka | Intervencija / gydymas |
|---|---|
| No Intervention: Water 250 ml of water mixed with 1g of citric acid. | |
| Active Comparator: Sugar 65g of sugar dissolved in 250ml of water | |
| Experimental: Stevia 5g of stevia dissolved in 250ml of water |
Tinkamumo kriterijai
| Amžius, tinkami studijuoti | 18 Years Į 18 Years |
| Tinkamos studijoms lytys | All |
| Priima sveikus savanorius | Taip |
| Kriterijai | Inclusion Criteria: - Age 18-65 years - BMI 27-40 Kg/m2 - Males and females Exclusion Criteria: - Athletes - Pregnant or breastfeeding women - Patients with chronic disease (diabetes, CVD etc…). |
Rezultatas
Pirminės rezultatų priemonės
1. Postprandial glucose levels [Capillary blood glucose will be measured two hours after the administration of a fixed meal.]
Antrinės rezultatų priemonės
1. Postprandial insulin levels [Postprandial insulin levels will be measured two hours of the administration of a fixed meal]
2. Area under the curve (AUC) for glucose [Capillary blood glucose levels will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch]
3. Subjective feelings of satiety [VAS will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch.]
