Chinese Journal of Natural Medicines 2014-Oct
A lignin glycoside and a nortriterpenoid from Kadsura coccinea.
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OBJECTIVE
To study the chemical constituents of the roots and stem bark of Kadsura coccinea.
METHODS
Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS.
RESULTS
Two compounds were determined as (7'S,8'S,8R)-(8β,8'α)-dimethyl-4,4'-dihydroxy-5,3'-dimethoxy-5'-cyclolignan glucoside (1) and micrandiactone H (2), respectively.
CONCLUSIONS
Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.
