Yao xue xue bao = Acta pharmaceutica Sinica 2006-Oct
[Active constituents from Aloe arborescens as BACE inhibitors].
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
Nuoroda įrašoma į mainų sritį
Raktažodžiai
Santrauka
OBJECTIVE
To seek for new components as BACE inhibitors from Aloe arborescens.
METHODS
The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.
RESULTS
Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.
CONCLUSIONS
Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.
