[The synthesis and pharmacological activities of analogs of erycibe alkaloid II].
Raktažodžiai
Santrauka
The C2 deoxy and C6 electron isosteric analogs of a new antiglaucoma agent, erycibe alkaloid II, were designed and synthesized. The main pharmacological results were as follows: 1. The C2-OH in erycibe alkaloid II was one of the key groups for its myotic activity; 2. It was worth noting that compounds 2 and 4 showed cholinergic and anticholinergic activities, respectively. This phenomenon in tropane alkaloids was not reported before; 3. The C6 electron isosteric compounds 16 and 17 showed neither anticholinergic nor cholinergic activities.