Boron neutron capture therapy for clear cell sarcoma

Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare, malignant tumor arising in lower extremities with no effective treatment other than wide surgical resection. Here described is a case of primary CCS in the peroneal tendon of the right foot of a 54-year-old woman enrolled to undergo BNCT. The tumor mass post-BNCT disappeared totally without damage to other normal tissue, demonstrating, for the first time, the potential efficacy of BNCT in complete local control of CCS.

Keywords: Boron neutron capture therapy (BNCT); CD98; Clear cell sarcoma of tendons and aponeuroses; Clinical treatment; L-type amino acid transporter 1 (LAT1); p-borono-l-phenylalanine (BPA).