ajugarin 1/vaisgina

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Ajugatansins, neo-clerodane diterpenes from Ajuga reptans.

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New neo-clerodane diterpenes have been isolated from Ajuga reptans, and named ajugatansins, along with the previously reported ajugavensin A and ajugareptansone A. The structures of all the compounds were elucidated by spectroscopic means and comparison with closely related compounds reported in the

A new phthalic acid ester from Ajuga bracteosa.

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A new phthalic acid ester 1,2-benzenedicarboxylic acid bis(2S-methyl heptyl) ester (1) was isolated from the hexane extract of the whole plant of Ajuga bracteosa. In addition, chloroform and methanol extracts yielded neo-clerodane diterpene ajugarin-I and two iridoid glycosides, reptoside and

neo-Clerodane Diterpenoids from Ajuga macrosperma var. breviflora.

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Six new naturally occurring ajugarin-like neo-clerodane diterpenoids, ajugaflorins A-F, along with six known compounds [the parent ajugarin I, ajugalides B and C, ajugamarin F4, ajugamacrin E, and ajugatakasin B] were isolated from A. macrosperma var. breviflora. The structures were elucidated by

Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.

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Treatment and control of malaria have become more difficult with the spread of drug-resistant parasites and insecticide-resistant mosquito vectors. In the search for new antimalarial drugs, ethnopharmacological sources should merit more attention. Establishing the safety of traditional herbal

Flavonol and iridoid glycosides of Ajuga remota aerial parts.

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Six flavonol glycosides characterised as myricetin 3-O-alpha-rhamnosyl-(1'''-->2'')-alpha-rhamnoside-3'-O-alpha-rhamnoside, 5'-O-methylmyricetin 3-O-[alpha-rhamnosyl (1'''-->2'')][alpha-rhamnosyl (1''''-->4'')]-beta -glucoside-3'-O-beta-glucoside, 5'-O-methylmyricetin 3-O-alpha-rhamnosyl

Isolation and identification of neo-clerodane diterpenes from Ajuga remota by high-performance liquid chromatography.

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In order to explore the suitability of reversed-phase HPLC for the rapid isolation, identification and semi-preparative fractionation of neo-clerodane diterpenes from Ajuga remota, an extract from aerial parts of the plant was examined using a C18 column with UV detection and gradient elution with

Antimycobacterial ergosterol-5,8-endoperoxide from Ajuga remota.

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In a bioassay-guided search for antimycobacterial natural products from higher plants, we have chemically investigated the methanol extract of aerial parts of Ajuga remota Benth. (Labiatae) for its active constituent(s). Bioactive chromatographic fractions of the crude extract provided the known

The antiplasmodial activity of isolates from Ajuga remota.

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Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Its two known isolates ajugarin-1 (1) and ergosterol-5,8-endoperoxide (3) and a new isolate 8-O-acetylharpagide (2) were evaluated for their in vitro antiplasmodial activity. Ajugarin-1 was moderately active,

NMR shift data of neo-clerodane diterpenes from the genus Ajuga.

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The complete assignment of the NMR spectra of ajugarin I and ajugareptansin, as models for other neo-clerodane diterpenoids isolated from the genus Ajuga, is reported in order to improve their usefulness as reference compounds. Conflicting NMR shift data for some members of this group are discussed,

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