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StraipsniaiKlinikiniai tyrimaiPatentai
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Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model.

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Prisijungti Registracija
Compelling epidemiologic studies indicate that obesity is a risk factor for many human cancers, including thyroid cancer. In recent decades, the incidence of thyroid cancer has dramatically increased along with a marked rise in obesity prevalence. We previously demonstrated that a high fat diet

Metformin and JQ1 synergistically inhibit obesity-activated thyroid cancer.

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Prisijungti Registracija
Compelling epidemiological evidence shows a strong positive correlation of obesity with thyroid cancer. In vivo studies have provided molecular evidence that high-fat-diet-induced obesity promotes thyroid cancer progression by aberrantly activating leptin-JAK2-STAT3 signaling in a mouse model of

Metformin blocks progression of obesity-activated thyroid cancer in a mouse model.

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Prisijungti Registracija
Compelling epidemiologic evidence indicates that obesity is associated with a high risk of human malignancies, including thyroid cancer. We previously demonstrated that a high fat diet (HFD) effectively induces the obese phenotype in a mouse model of aggressive follicular thyroid cancer

Diet-induced obesity increases tumor growth and promotes anaplastic change in thyroid cancer in a mouse model.

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Recent epidemiological studies provide strong evidence suggesting obesity is a risk factor in several cancers, including thyroid cancer. However, the molecular mechanisms by which obesity increases the risk of thyroid cancer are poorly understood. In this study, we evaluated the effect of
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