Standard Artemisinin Combination Therapy (ACT) being used as currently approved antimalarial therapy at WHO and manufacturer recommended dosage. The specific ACT used is artemether-lumefantrine (Coartem). Form is scored tablets that each contain 20 mg artemether and 120 mg lumefantrine.
Tablets per dose, are given BID for 3 days as shown below:
Coartem tablets/dose by bodyweight; tablets/day morning and evening for total of 6 doses over 3 days
Body weight (kg) and Tablets: 5 to <15 kg, 1 tab; 15 to <25 kg, 2 tabs; 25 to <35 kg, 3 tabs; 35 kg and over, 4 tabs.

Dried leaf Artemisia annua (DLA) from 0.25-1 g total/day, BID. DLA is given as 500 mg tablets according to body weight (see below) for 5 days.
DLA tablets/dose by bodyweight; tablets/day, morning and evening, for total of 10 doses over 5 days.
Body weight (kg) and tablets/dose:
For DLA1x: 5 to < 15 kg, 1/4 tab; 15-30 kg, 1/2 tab; 1/2>30 kg, 1 tab.

Dried leaf Artemisia annua (DLA) from 0.5-2 g total/day, BID. DLA is given as 500 mg tablets according to body weight (see below) for 5 days.
DLA tablets/dose by bodyweight; tablets/day, morning and evening, for total of 10 doses over 5 days.
Body weight (kg) and tablets/dose:
For DLA2x: 5 to < 15 kg, 1/2 tab; 15-30 kg, 1 tab; >30 kg, 2 tabs.

Malaria

Current approved drug for treating malaria

Experimental drug treatment, single dose.

DLA1

Experimental drug treatment, doubled the dose of DLA1.

DLA2

Rwanguba Reference Hospital

Dried Leaf Artemisia (DLA) Compared to Artemisinin Combination Therapy (ACT) vs Malaria

Efficacy of Dried Leaf Artemisia (DLA) Versus Coartem (ACT): A Randomized Controlled Clinical Trial for Comparing DLA vs. ACT to Treat Malaria

Use microscopy and qPCR to compare change in gametocyte carriage among the 3 treatment arms.

Use microscopy to measure and compare parasitemia elimination in the blood of patients among the 3 treatment arms.

Compare patient side effects observationally measured among the 3 treatment arms.

artemether/kietis

Dried Leaf Artemisia (DLA) Compared to Artemisinin Combination Therapy (ACT) vs Malaria

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