artemether/seizures

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Comparative efficacy of intramuscular artemether and intravenous quinine in Nigerian children with cerebral malaria.

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The efficacy of a 5-day treatment with intramuscular artemether (3.2-mg/kg loading dose followed by 1.6 mg/kg daily) was compared to that of the standard 7-day treatment with quinine (20-mg/kg loading dose followed by 10 mg/kg every 8 h) in a randomised clinical trial including 103 children aged

[Comparison of the effectiveness of artemether and quinine for treatment of severe malaria in children, Bangui, Central African Republic].

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The management of severe malaria is a major challenge in the health care services in sub-Saharan Africa. This study aimed to assess the efficacy and safety of artemether and quinine in severe malaria at Complexe pédiatrique of Bangui, Central African Republic. A total of 212 children among 1125

Differential effects of orally versus parenterally administered qinghaosu derivative artemether in dogs.

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Artemether (AM) is an antimalarial drug derived from artemisinin (Qinghaosu), an extract of the herb Artemisia annua L., sweet wormwood. Its antiparasitic effect is that of a schizontocide and is explained by rapid uptake by parasitized erythrocytes and interaction with a component of hemoglobin

Fatal neurotoxicity of arteether and artemether.

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Artemisinin (qinghaosu) and several derivatives have been developed and are in use as antimalarial drugs but scant information is available regarding animal or human toxicity. Following a eight-day, multiple-dose, pharmacokinetic study of arteether (AE) (10 mg/kg/day [n = 6] and 20 mg/kg/day [n =

Anti-plasmodial effects of Azadirachta indica in experimental cerebral malaria: Apoptosis of cerebellar Purkinje cells of mice as a marker.

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BACKGROUND Malaria is a major public health problem in the world, but treatment of malaria is becoming more difficult due to increasing drug resistance. Therefore, the need for alternative drugs is acute. OBJECTIVE This study investigated the antiplasmodial and protective effect of an ethanolic

Clinical spectrum and treatment outcome of severe malaria caused by Plasmodium vivax in 18 children from northern India.

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OBJECTIVE The study was intended to document the clinical profile and treatment outcome of severe malaria caused by Plasmodium vivax (P.vivax) in children hospitalized in a tertiary care centre of northern India. METHODS This prospective observational study was performed among children admitted with

UK malaria treatment guidelines.

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Malaria is the tropical disease most commonly imported into the UK, with 1500-2000 cases reported each year, and 10-20 deaths. Approximately three-quarters of reported malaria cases in the UK are caused by Plasmodium falciparum, which is capable of invading a high proportion of red blood cells and

Antiepileptic properties of Quinine: A systematic review.

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BACKGROUND Quinine has anti-epileptic properties in animals. However, in humans this has not been systematically investigated. OBJECTIVE To examine the available research evidence on the effects of quinine on seizures in adults or children. METHODS We searched online databases for published and

Severe malaria management: current situation, challenges and lessons learned from Gezira State, Sudan.

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The present study aimed to evaluate the management of severe malaria at Gezira State hospitals in Sudan by assessing hospital readiness, health care provider knowledge and the care received by severe malaria patients.A cross-sectional descriptive study was

Mild encephalitis/encephalopathy with a reversible splenial lesion due to Plasmodium falciparum malaria: a case report.

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UNASSIGNED Neurological complications from malaria cause significant morbidity and mortality. Severe cerebral malaria occurs as a result of intense sequestration of infected erythrocytes in the cerebral capillaries. However, the pathology of the reversible neurological symptoms remains unclear. We

UK malaria treatment guidelines 2016.

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1.Malaria is the tropical disease most commonly imported into the UK, with 1300-1800 cases reported each year, and 2-11 deaths. 2. Approximately three quarters of reported malaria cases in the UK are caused by Plasmodium falciparum, which is capable of invading a high proportion of red blood cells

Treatment of cerebral malaria and acute respiratory distress syndrome (ARDS) with parenteral artesunate.

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Infection with Plasmodium Falciparum can cause a severe form of malaria with multiorgan involvement. Cerebrum is one of the organs involved in the P. Falciparum malaria, which can lead to coma, convulsions, and other neurological sequel. The sequestration of cerebral vasculature with parasitized red

Pre-referral rectal artesunate for severe malaria.

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BACKGROUND Severe or complicated malaria is a medical emergency and people die as a result of delays in starting treatment. Most patients need parenteral treatment, and in primary healthcare facilities, where intravenous therapy is not available but intramuscular injections can be given,

Neuregulin-1 attenuates mortality associated with experimental cerebral malaria.

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BACKGROUND Cerebral Malaria (CM) is a diffuse encephalopathy caused by Plasmodium falciparum infection. Despite availability of antimalarial drugs, CM-associated mortality remains high at approximately 30% and a subset of survivors develop neurological and cognitive disabilities. While antimalarials

Drug-Drug-Induced Akathisia: Two Case Reports.

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Extrapyramidal side effects of psychotropic medicines are usually experienced by patients in the first few weeks of initiating therapy. Patients stabilized on these medications who present with distressing complaints akin to akathisia may be triggered by other factors. This report presents two cases

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