Disclosed is a commercially viable asiaticoside composition having at least 99% purity that is derived from plant Centella asiatica and a manufacturing process thereof. Also disclosed is a method and the models for oral administration of therapeutically effective amounts of the asiaticoside composition for treatment of Inflammatory Bowel Diseases such as Ulcerative colitis, Crohn's disease and associated complications of inflammatory bowel diseases such as hemorrhoids, anal fissures, fistulas. Also disclosed is a method and model for oral administration of therapeutically effective amounts of the asiaticoside composition for treatment of Helicobacter Pylori, as well as a method and the models for oral administration of therapeutically effective amounts of the asiaticoside composition for prevention of colon cancer, gastric diseases and gastric carcinoma.

Bhaskaran; Sunil

Vishwaraman; Mohan

Indus Biotech Private Limited

Method for preparation of highly pure asiaticoside composition from Centella asiatica and a method of use thereof

A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.

Liu; Ying

Liu; Quanhai

Qin; Yan

Wu; Tong

Xu; Zhiru

Liu; Min-yu

Li; Fei

Li; Yan

Newman; Michael J.

Shanghai Institute of Pharmaceutical Industry

Therapeutic formulations based on asiatic acid and selected salts thereof

The invention concerns an extract of Centella asiatica comprising more than 75 wt. % of a mixture of madecassoside, terminoloside and asiaticoside, relative to the extract total weight, an extract of Centella asiatica comprising more than 95 wt. % of a mixture of madecassoside and terminoloside relative to the extract total weight and their use for regulating inflammatory mechanisms.

Loiseau; Alain

Sene; Gerard

Theron; Eric

Bayer Consumer Care AG

Method for preparing a Centella asiatica extract rich in madecassoside and in terminoloside

The invention concerns a method for preparing an extract comprising a mixture of madecassoside, terminoloside and optionally asiaticoside, an extract of Centella asiatica comprising more than 75 wt % of a mixture of madecassoside, terminoloside and asiaticoside, relative to the extract total weight, an extract of Centella asiatica comprising more than 95 wt. % of a mixture of madecassoside and terminoloside relative to the extract total weight and their use for regulating inflammatory mechanisms.

asiaticoside

uždegimas

inflammation

asiaticoside/uždegimas

Method for preparation of highly pure asiaticoside composition from Centella asiatica and a method of use thereof

Therapeutic formulations based on asiatic acid and selected salts thereof

Method for preparing a Centella asiatica extract rich in madecassoside and in terminoloside

Method for preparing a Centella asiatica extract rich in madecassoside and in terminoloside

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