Novel carboxylic acids of formula (VI), useful for preparing taxane derivatives of general formula (I) by esterifying protected baccatine (III) or protected diacetyl baccatin (III) with an acid of general formula (II). The products of general formula (I) are particularly useful for preparing taxol, Taxotere and analogs thereof having anti-tumor properties. ##STR1##

Aventis Pharma S.A.

Carboxylic acids for synthesis of taxane derivatives

The invention is an oxazolidine ester of silylated baccatin III of formula (VII) ##STR1##which is a useful intermediate to produce pharmaceutically useful anti-cancer compounds.

baccatin iii/vėžys

Carboxylic acids for synthesis of taxane derivatives

Process to prepare taxol

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