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Evaluating Safety & Efficacy of Apremilast in the Treatment of Cutaneous Disease in Patients With Recalcitrant Dermatomyositis

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1. Sponsor Name (PI): Carole Bitar, MD 2. Sub-PI: Erin Boh, MD, PhD; Brittany Stumpf, MD; Collaborator: Nakhle Saba, MD 3. # of Participants Sites: 1, Tulane University 4: Participant Countries: United States II. PRODUCT INFORMATION 1. Study Title: A phase 2, open label single arm study for

A Study to Assess Renal Function Response to Treatment in Patients With Relapsed Multiple Myeloma and Creatinine Clearance

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Prospective, multicentre, post-authorisation observational study. Study population: Patients with relapsed multiple myeloma and with CrCl <50 mL/min/1.73 m2, for whom the investigator decides to start a new line of anti-myeloma treatment as per normal clinical practice. The decision to prescribe

Genetics of Ehlers-Danlos Syndrome

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Ehlers-Danlos Syndrome (EDS) is a genetic disease that affects collagen synthesis and structure resulting in multisystem connective tissue involvement with twelve different subtypes. The clinical manifestations of EDS include skin hyperextensibility, skin fragility, joint hypermobility, muscle

Medical Management of Late Intrauterine Death.

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A prospective, randomised, double-blind, controlled clinical trial (RCT) was conducted to compare the efficacy and clinical safety of the induction of labour using the combination of isosorbide dinitrate-oxytocin (experimental arm, X = 1) compared to misoprostol-oxytocin (standard arm, X = 0). The

The Use of Modified ride-on Cars to Advance Mobility and Socialization in Young Children With Disabilities

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Children with mobility disabilities have more limited opportunities to explore their environment; therefore, they are considered to be at risk of secondary impairments, such as cognitive, spatial-perceptual, and social-emotional delay. Independent mobility is believed to be essential for

Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial

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Research Design and Methods: The study will be a multicenter, randomized, controlled, clinical trial comparing the anti-seizure effect of parenteral and/or oral labetalol (n = 4000) versus parenteral (intravenous or intramuscular) magnesium sulfate (n = 4000) with mild or severe preeclampsia who are

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