Group 1 (acetazolamide): Patients undergoing RALP with the peri-operative use of one-time 250 mg dose of acetazolamide

Group 2 (placebo): Patients undergoing RALP with the peri-operative use of 10 mL normal saline as placebo.

Prostate Cancer

Males having a robotic-assisted prostatectomy

Being that adequate pain control is essential to recovery in the post-operative setting, efforts have been made to address this pain at its root. Prior studies have demonstrated that preoperative administration of acetazolamide decreased post-operative referred pain in the immediate post-surgical period.

Acetazolamide

Placebo

Froedtert Memorial Lutheran Hospital

Impact of Acetazolamide in Reducing Referred Postoperative Pain

Impact of Acetazolamide in Reducing Referred Postoperative Pain After Robotic Assisted Laparoscopic Prostatectomy

The primary outcome to be assessed is the absolute change in VAS score both in general and at the shoulder tip. This will be measured as the difference between the VAS score obtained pre-operatively, when first responsive after surgery in the post anesthesia care unit (PACU), immediately prior to leaving PACU, and throughout the hospital stay per standard of care.
Δ VAS = Postoperative VAS - Preoperative VAS VAS is a testing technique for measuring subjective or behavioral phenomena (as pain or dietary consumption) in which a subject selects from a gradient of alternatives (as from "no pain" to "worst imaginable pain" or from "every day" to "never") arranged in linear fashion —abbreviation VAS

Scott Johnson

Assistant Professor

Medical College of Wisconsin

patients randomized to this arm are given ringer's lactate solution for cardiopulmonary bypass prime, which is the standard practice

patients randomized to this arm are given Plasma Lyte - A solution for cardiopulmonary bypass prime

Cardiopulmonary Bypass

Plasma Lyte -A is administered intra operatively to maintain the hemodynamic status of patients

Plasmalyte A

Ringer's lactate is administered intra operatively to maintain the hemodynamic status of patients

Ringer Lactate

Comparative Analysis Between Ringer's Lactate vs Plasma Lyte-A as Cardiopulmonary Bypass Prime

Comparative Analysis Between Ringer's Lactate vs Acetate Containing Balanced Crystalloid Solution (Plasma Lyte-A) as Cardiopulmonary Bypass Prime

Arterial blood gas analysis at before induction, five minutes after CPB, at the end of the termination of CPB, half an hour stay in the ICU soon after the patient is shifted from completion of surgery, before the patient is extubated

carbonic acid/kraujavimas

Impact of Acetazolamide in Reducing Referred Postoperative Pain

Comparative Analysis Between Ringer's Lactate vs Plasma Lyte-A as Cardiopulmonary Bypass Prime

Išsamiausia vaistinių žolelių duomenų bazė, paremta mokslu