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convallatoxin/convallaria
Nuoroda įrašoma į mainų sritį
9 rezultatus
Convallatoxin: a new P-glycoprotein substrate.
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Digitalis-like compounds (DLCs), such as digoxin and digitoxin that are derived from digitalis species, are currently used to treat heart failure and atrial fibrillation, but have a narrow therapeutic index. Drug-drug interactions at the transporter level are frequent causes of DLCs toxicity.
Convallatoxin, the active cardiac glycoside of lily of the valley, minimally affects the ADVIA Centaur digoxin assay.
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OBJECTIVE
Lily of the valley is a poisonous plant due to the presence of the cardiac glycoside convallatoxin which is known to interfere with serum digoxin measurement using the LOCI digoxin assay and other digoxin assays. We evaluated potential interference of convallatoxin as well as extract of
The iDigoxin Assay is More Sensitive than LOCI Digoxin Assay for Rapid Detection of Convallatoxin, the Active Cardiac Glycoside of Lily of The Valley.
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OBJECTIVE
Lily of the valley is a poisonous plant due to the presence of the cardiac glycoside convallatoxin. We compared two immunoassays (LOCI digoxin assay and iDigoxin assay) for rapid detection of convallatoxin if present in human serum.
METHODS
Aliquots of a drug free serum pool and a digoxin
Rapid detection of convallatoxin using five digoxin immunoassays.
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BACKGROUND
Cardiac glycosides of plant origin are implicated in toxic ingestions that may result in hospitalization and are potentially lethal. The utility of commonly available digoxin serum assays for detecting foxglove and oleander ingestion has been demonstrated, but no studies have evaluated
Rapid detection of the active cardiac glycoside convallatoxin of lily of the valley using LOCI digoxin assay.
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OBJECTIVE
To explore the luminescent oxygen channeling technology-based digoxin immunoassay (LOCI digoxin assay) for rapid detection of lily of the valley extract and convallatoxin. The potential in vitro binding of convallatoxin with Digibind was also evaluated.
METHODS
Aliquots of a drug-free
[Comparative standardization of Convallaria drugs and convallatoxin in guinea pigs].
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[Cardenolide glycosides of Convallaria majalis. II. Assay of convallatoxin and locundioside].
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Studies on the Turnover of Cardenolides in Convallaria majalis.
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In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2)
The positive inotropic effect of the aqueous extract of Convallaria keiskei in beating rabbit atria.
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The positive inotropic effect of the aqueous extract of Convallaria keiskei (ACK) and the possible mechanisms responsible for this effect were investigated in beating rabbit atria. ACK significantly increased atrial stroke volume, pulse pressure, and cAMP efflux in beating rabbit atria. The effects
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