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cyclopeptide/nekrozė
Nuoroda įrašoma į mainų sritį
4 rezultatus
Structure-Based Design, Synthesis and Bioactivity of a New Anti-TNFα Cyclopeptide.
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Prisijungti Registracija
As opposed to small molecules, macrocyclic peptides possess a large surface area and are recognised as promising candidates to selectively treat diseases by disrupting specific protein-protein interactions (PPIs). Due to the difficulty in predicting cyclopeptide conformations in solution, the de
[Toxicity of alpha-amanitin on mice in vivo].
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OBJECTIVE
To study the toxic effect of alpha-amanitin from Amanita fungi on mice in vivo.
METHODS
The LD50 of alpha-amanitin was determined with intravenous and intraperitoneal injections of alpha-amanitin. The mice were then injected intravenously with LD50 dose of alpha-amanitin, and the viscera
Amanitin toxicosis in two cats with acute hepatic and renal failure.
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Prisijungti Registracija
Amanitin is a toxic cyclopeptide present in several species of poisonous mushrooms. Amanitin toxicosis was diagnosed in 2 cats from separate premises. Both cats initially had lethargy and vomiting, and they rapidly developed depression and neurological signs over 24-48 hours. Marked elevation of
RA-XII exerts anti-oxidant and anti-inflammatory activities on lipopolysaccharide-induced acute renal injury by suppressing NF-κB and MAPKs regulated by HO-1/Nrf2 pathway.
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Acute kidney injury (AKI) is an abrupt loss of kidney function and severe AKI needs renal replacement therapeutic strategy and has high mortality. RA-XII is a natural cyclopeptide, isolated from the traditional Chinese medicine Rubia yunnanensis, exerting anti-inflammatory and anti-tumor activities.
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