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desoxyribonuclease/uždegimas
Nuoroda įrašoma į mainų sritį
6 rezultatus
Lupus and desoxyribonuclease.
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Prisijungti Registracija
The dominant autoantigen in SLE is the nucleosome and immune complexes involving nucleosomes are the major cause of tissue damage. Nucleosomes can be broken down in vivo with Desoxyribonuclease 1. DNase 1 from humans and mice is inhibited by actin and it is proposed that the release of platelet
Desoxyribonuclease activity in the serum and spleen of rats with mycoplasma induced arthritis.
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Prisijungti Registracija
The endodesoxyribonuclease and exodesoxyribonuclease activities were measured in the spleen cytoplasma fraction and serum of rats with mycoplasma induced arthritis and adjuvant arthritis. A higher exonuclease activity was found in the spleen cytoplasma of adjuvant arthritis rats. During the
Contrast-enhanced magnetic resonance imaging (MS-325) in a murine model of systemic lupus erythematosus.
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OBJECTIVE
To investigate whether inflammatory activity can be evaluated by MRI with an intravascular compound (MS-325) in Desoxyribonuclease I (Dnase1)-deficient mice, which show classical symptoms of systemic lupus erythematosus.
METHODS
Dnase1-deficient and normal mice (both groups n = 10)
Role of soluble and cell surface molecules in the pathogenesis of autoimmune skin diseases.
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Prisijungti Registracija
The skin is one of the most commonly involved tissue in rheumatic autoimmune diseases. Different mechanisms are thought to be implicated in the pathogenesis of skin lesions. In genetically predisposed individuals, ultraviolet (UV) light can contribute to the induction of skin lesions via an
[Use of deoxyribonuclease in the therapy of the neoplastic patient].
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The anti-inflammatory actvity of desoxyribonuclease has been demonstrated on a number of occasions. It has been suggested that its particular features may mean that it possesses an antineoplastic action, especially if employed in asociation with radiation or chemotherapy. The drug, which
Immunogenic cell death biomarkers HMGB1, RAGE, and DNAse indicate response to radioembolization therapy and prognosis in colorectal cancer patients.
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Prisijungti Registracija
Radioembolization therapy (RE) is an efficient locoregional treatment for liver metastases from colorectal cancer. Serum biomarkers involved in immunogenic cell death are potentially valuable for early predicting therapy response and estimating prognosis. In a prospective observation study, blood
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