dl lactic acid/uždegimas

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Development of an oral drug delivery system targeting immune-regulating cells in experimental inflammatory bowel disease: a new therapeutic strategy.

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Several studies have indicated the involvement of macrophages and dendritic cells in active inflammatory bowel disease (IBD). Manipulation of these cells is considered a very important therapeutic strategy for patients with IBD. We evaluated the effect of a new drug delivery system targeting

Synergic modulation of the inflammatory state of macrophages utilizing anti-oxidant and phosphatidylserine-containing polymer-lipid hybrid nanoparticles.

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Inflammatory activation of macrophages is a key factor in chronic inflammatory diseases such as ulcerative colitis. The excessive production of reactive oxygen species (ROS)/reactive nitrogen species (RNS) by macrophages causes oxidative stress during the inflammatory response and exaggerates

Molecular biointeractions of biomedical polymers with extracellular exudate and inflammatory cells and their effects on the biocompatibility, in vivo.

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The stability of biomedical polymers in physiological environments is crucial for the normal operation of devices, as well as determining their effect on the tissue response. Degradation is an important factor in polymer biocompatibility, since the environment of the human body can be aggressive to

[Experimental research on degradation and biocompatibility of super-high-molecular-weight poly-DL-lactic acid].

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OBJECTIVE The super-high-molecular-weight poly-DL-lactic acid (PDLLA), with the molecular weight of 900 kD, is a newly emerging biomaterial and potentially used in the therapy of bone fracture because of its excellent mechanical property. However the biocompatibility of this material has not been

[A prospective randomized trial of poly-DL-lactic acid absorbable and metallic screws for treatment of syndesmotic disruptions].

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OBJECTIVE To compare the clinical effect of poly-DL-lactic acid (PDLLA) absorbable screws and titanium metallic screws in the treatment of syndesmotic disruptions in ankle fractures. METHODS In this prospective, randomized clinical trial, 58 patients with or suspected of syndesmotic disruption

[Histological evaluation of domestic poly-DL-lactic acid membranes for periodontal guided tissue regeneration].

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OBJECTIVE To evaluate the possibility of domestic poly-DL-lactic acid membranes as barriers during periodontal guided tissue regeneration. METHODS Two-wall intrabony defects were made by artificially removing buccal and distal alveolar bone from the distal roots of the second, third and fourth

Effects of biodegradable self-reinforced polyglycolic acid, poly-DL-lactic acid and stainless-steel spiral stents on uroepithelium after Nd:YAG laser irradiation of the canine prostate.

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OBJECTIVE To evaluate the safety and tissue effects on canine uroepithelium and prostate of biodegradable self-reinforced polyglycolic acid (SR-PGA) and self-reinforced poly-DL-lactic acid (SR-PLA) spiral stents compared to stainless-steel (SS) spiral stents. METHODS Twenty-five dogs (median body

In vivo and in vitro degradation of glycine/DL-lactic acid copolymers.

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A series of copolymers of glycine and DL-lactic acid with various compositions was synthesized and their in vivo and in vitro degradation behavior was studied. For the in vivo examination, discs of the copolymer films were subcutaneously implanted in rats. The in vitro studies were carried out in

Biocompatibility and effect on osteogenesis of poly(ortho ester) compared to poly(DL-lactic acid).

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Implantation of demineralized bone induces new bone formation by the action of contained growth factors, of which bone morphogenetic proteins are of prime importance. A biodegradable polymer may be used as a carrier for demineralized bone particles or recombinant bone growth factors to prevent

The treatment response of barrier membrane with Amoxicillin-loaded nanofibers in experimental periodontitis

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Background: Infection control is a major determinant of guided tissue regeneration (GTR). This study aimed to develop an antibiotic-loaded membrane to assist periodontal repair. Methods:

Failure of resorbable plates and screws in an ovine model of anterior cervical discectomy and fusion.

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BACKGROUND Containment plates are often placed anteriorly in anterior cervical discectomy and fusion (ACDF) to provide stability and prevent migration of the interbody device or autograft. The main advantage of a bioresorbable plate over the typical metallic plate is that it will resorb after fusion

Biodegradable Fixation of the Orbital Rim After Lateral Orbitotomy.

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OBJECTIVE To describe authors' experience with repair of the lateral orbital rim with poly-L/DL-lactic acid (PDLLA) biodegradable plates using ultrasonic pin fixation after lateral orbitotomy with bone flap. METHODS The authors retrospectively reviewed all patients who underwent a lateral orbitotomy

Biodegradable fixation for craniomaxillofacial surgery: a 10-year experience involving 761 operations and 745 patients.

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Patient acceptance, safety, and efficacy of poly-l/dl-lactic acid (PLLDL) bone plates and screws in craniomaxillofacial surgery are reported in this article. Included in the sample are 745 patients who underwent 761 separate operations, including more than 1400 surgical procedures (orthognathic

Bone formation with use of rhBMP-2 (recombinant human bone morphogenetic protein-2).

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We examined the effect of rhBMP-2 (recombinant human bone morphogenetic protein-2), delivered in a porous poly(DL-lactic acid) implant, on bone formation in a critical-sized defect in the radial diaphysis in rabbits. A unilateral segmental defect, twenty millimeters long, was created in the radius

Early experience with biodegradable implants in pediatric patients.

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We retrospectively studied nine children and adolescents with congenital malformations, large reconstruction after tumor excision, fractures and osteotomies of the upper extremity, and hand trauma with bone and soft tissue defects treated by internal synthesis using a biocopolymer of L- and

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