The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant Dysoxylum binectariferum. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-- one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits production of pro-inflammatory cytokines. The formulations of this particular compound can be used for treatment of cancer and inflammation. ##STR00001##

Council of Scientific &amp; Industrial Research

COUNCIL OF SCIENTIFIC &amp; INDUSTRIAL RESEARCH

Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders

The present invention discloses eight new diterpenoids, i.e. Dysongensins A to H, extracted from the leaves and twigs of Dysoxylurn hongkongense, wherein AMBROX.RTM. which is applicable in the perfume industry is prepared from Dysongensin A via a series of chemical reactions, and the cytotoxicity of Dysongensins A to H against human cancer cell lines and their antiviral and anti-inflammatory activities are determined. Therefore, in the present invention, AMBROX.RTM. prepared from Dysongensin A is a new idea for application as an odorous compound in the perfume industry, and the novel diterpenoids can be prepared as a pharmaceutical compositions and/or a drug having antiviral, anti-inflammatory and/or anti-cancer activities.

National Taiwan University

NATIONAL TAIWAN UNIVERSITY

Preparation of ambrox from labdanes of Dysoxylum hongkongense, and the preparation of new diterpenoids from Dysoxylum hongkongense

dysoxylum ficiforme

uždegimas

inflammation

dysoxylum

dysoxylum ficiforme/uždegimas

Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders

Preparation of ambrox from labdanes of Dysoxylum hongkongense, and the preparation of new diterpenoids from Dysoxylum hongkongense

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