14 rezultatus
The present invention relates to a group of secondary amine derivatives that possess anti-obesity and anti-hyperglycaemic properties, to the method of their preparation and to their use as anti-obesity and/or anti-hyperglycaemic agents when formulated into a pharmaceutical composition.
Certain of
The present invention relates to new substituted phenoxyacetates of cyclic amines, a method for their preparation and applications thereof as medicaments.
There are already known substituted phenoxyacetate derivatives, and in particular dimethylaminoethyl 4-chloro-phenoxyacetate, which is currently
BACKGROUND OF THE INVENTION
The present invention relates to Indole derivatives, intermediates for their preparation, pharmaceutical compositions containing therm, and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other disorders.
U.S. Pat.
The present invention relates to a group of secondary amine derivatives that possess anti-obesity and anti-hyperglycaemic properties, to the method of their preparation and to their use as anti-obesity and/or anti-hyperglycaemic agents when formulated into a pharmaceutical composition.
Certain of
The present invention relates to a group of secondary amine derivatives that possess anti-obesity and anti-hyperglycaemic properties, to the method of their preparation and to their use as anti-obesity and/or anti-hyperglycaemic agents when formulated into a pharmaceutical composition.
Certain of
The present invention relates to a group of secondary amine derivatives that possess anti-obesity and anti-hyperglycaemic properties, to the method of their preparation and to their use as anti-obesity and/or anti-hyperglycaemic agents which formulated into a pharmaceutical composition.
Certain of
The present invention relates to a group of secondary amine derivatives that possess anti-obesity and anti-hyperglycaemic properties, to the method of their preparation and to their use as anti-obesity and/or anti-hyperglycaemic agents when formulated into a pharmaceutical composition.
Certain of
This application is filed pursuant to 35 U.S.C. .sctn. 371 as a United States National Phase Application of International Application No. PCT/EPO1/14887 filed Dec. 18, 2001, which claims priority from 0031109.2 filed Dec. 20, 2000.
The present invention relates to certain novel compounds. In
The present invention is concerned with novel oxazolidines, a process for their manufacture and pharmaceutical preparations based on these compounds.
The oxazolidines in accordance with the invention are compounds of the formula ##STR2## wherein n is the number 1 or 2,
T is lower-carbalkoxy,
X is
BRIEF DESCRIPTION OF THE INVENTION
The present invention is directed to compounds of the formula ##STR6## and pharmaceutically acceptable salts thereof. As used in formula I, and throughout the specification, the symbols have the following meanings: ##STR7## R.sub.4 is hydroxy, alkoxy, amino,
BRIEF SUMMARY OF THE INVENTION
The invention relates to tertiary and secondary amines of the formula ##STR2## wherein n is the integer 1 of 2,
R is hydrogen, lower-alkanoyl or phenyl-lower-alkanoyl,
X.sup.1 is phenoxymethyl optionally mono-fluorinated or mono-chlorinated in the
BRIEF SUMMARY OF THE INVENTION
The invention relates to tertiary and secondary amines of the formula ##STR3## and ##STR4## wherein
n is the integer 1 to 2,
R is hydrogen, lower-alkanoyl or phenyl-lower-alkanoyl,
X.sup.1 is phenoxymethyl optionally mono-fluorinated or mono-chlorinated in the
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a U.S. National Phase application under 35 U.S.C. .sctn. 371 of PCT Application No. PCT/JP2004/013768, filed Sep. 21, 2004, which claims priority under 35 U.S.C. .sctn. 119 from Japanese Application No. JP2003-330758, filed Sep. 22,
TECHNICAL FIELD
The present invention relates to a novel piperidine derivative, to a histamine-H3 receptor antagonist containing the novel piperidine derivative as an active ingredient thereof, and to a preventive or remedy for metabolic system diseases, circulatory system diseases, central or